| Creation and anti-cancer potency in HeLa cells of a novel chimeric toxin,HMGNCIDIN, composed of HMGN2 α- helical domain and PE38 KDEL domain Ⅲ |
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| 引用本文： | Xiong WB,Huang N,Feng Y,Wu Q,Wang BY. Creation and anti-cancer potency in HeLa cells of a novel chimeric toxin,HMGNCIDIN, composed of HMGN2 α- helical domain and PE38 KDEL domain Ⅲ[J]. 中华医学杂志(英文版), 2008, 121(1): 82-85 |
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| 作者姓名： | Xiong WB Huang N Feng Y Wu Q Wang BY |
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| 作者单位： | Department of Pharmacology （Xiong WB）; Research Unit ofInfection ＆ Immunity （Huang N, Feng Y, Wu Q and Wang BY）,West China Medical Center, Sichuan University, Chengdu, Sichuan610041 ,China |
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| 基金项目： | This study was supported by grants from the China Methcal Board of New York Inc. （No. 98-681）, and the National Natural Science Foundation of China （No. 30470763 and No. 30671963）. |
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| 摘 要： | Using targeted toxins is a promising approach for the therapy of cancer and autoimmune diseases, as well as other disorders/The high mobility group chromosomal protein N2 （HMGN2） is one of the most abundant and well-characterized classes of nonhistone nuclear proteins, which seems to function as architectural elements in chromatin.2 Recently our group isolated an antimicrobial polypeptide from human LAK cells and cervical mucus,
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| 关 键 词： | 假单胞菌 外毒素 肿瘤嵌合体 医学实验 |
| 收稿时间： | 2007-05-30 |
Creation and anti-cancer potency in HeLa cells of a novel chimeric toxin, HMGNCIDIN, composed of HMGN2 a-helical domain and PE38 KDEL domain III |
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| Xiong Wen-bi,Huang Ning,Feng Yun,Wu Qi,Wang Bo-yao. Creation and anti-cancer potency in HeLa cells of a novel chimeric toxin, HMGNCIDIN, composed of HMGN2 a-helical domain and PE38 KDEL domain III[J]. Chinese medical journal, 2008, 121(1): 82-85 |
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| Authors: | Xiong Wen-bi Huang Ning Feng Yun Wu Qi Wang Bo-yao |
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| Affiliation: | 1. Department of Pharmacology,West China Medical Center, Sichuan University, Chengdu, Sichuan 610041,China
2. Research Unit of Infection & Immunity,West China Medical Center, Sichuan University, Chengdu, Sichuan 610041,China |
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| Abstract: | HMGN2a-helical domain pseudomonas exotoxin recombinant anti-cancer chimera |
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| Keywords: | HMGN2a-helical domain pseudomonas exotoxin recombinant anti-cancer chimera |
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