nm23在胚胎组织和肺癌组织中表达的意义

目的 探讨nm23-H1基因的表达与胚胎组织发育分化的关系和在肺癌组织中表达的意义。方法 对SD大鼠和人的胚胎组织，以及人肺癌组织进行nm23蛋白（NM23－H1）免疫组化检测。结果 NM23－H1的积聚与胚胎发育期间各种上皮组织的分化和器官形成相一致，正常胚胎组织要发育至一定阶段，具有一定空间构型（器官结构）时才有较稳定的NM23－H1积聚。在49例肺癌原发病灶中，NM23－H1阳性率34．7％，其中鳞癌的阳性率27．3％，腺癌的阳性率50．0％，5例未分化大细胞癌均阴性。27例肺门淋巴结转移癌灶的NM－23H1阳性率（22．2％）与原发瘤灶中的阳性率（34．7％）比较差异无显著性（P＞0．05）。在肺癌原发病灶中，NM23－H1阳性与阴性二组间淋巴结转移发生率的差异亦无显著性（P＞0．05）。结论 NM23－H1在胚胎组织和肺癌组织中的积聚与胚胎组织和肺癌组织器官样结构的分化有密切关系，NM23－H1可能对维持稳定的上皮组织结构起着重要的调节作用，NM23－H1似乎不能直接抑制肺癌细胞的转移。

The significance of nm23 gene expression in embryonic tissues and lung cancer tissues

Objective To clarify the relationship between nm23 H1 gene and differentiation of embryonic tissues and the significance of its expression in pulmonary carcinoma. Methods nm23 H1 protein (NM23 H1) was detected in the embryonic tissues of SD rats and human being, as well as in human lung cancer tissues, by immunohistochemistry method. Results Only embryonic tissues with definite configuration (organ structure) expressed NM23 H1 constantly. Positive rate of NM23 H1 was 34.7% in 49 cases of human lung cancer tissues, and 27.3% in squamous cell carcinoma, 50.0% in adenocarcinoma. The positive rate of NM23 H1 was 22.2% in 27 cases of hilar lymph node metastatic foci, and 34.8% in primary tumour foci (P>0.05). There was no significant difference of lymphatic metastatic rates between NM23 H1 positive and negative primary tumors. Conclusion There is positive correlation between accumulation of NM23 H1 and differentiation of embryonic tissues and lung carcinoma. NM23 H1 may play an important role in maintaining a stable epithelial structure. It doesn't show that NM23 H1 can directly inhibit the metastasis of lung cancer cells.