| 高功能孤独症患儿胼胝体及额叶体积的磁共振研究 |
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| 引用本文： | 张久平,洪珊珊,柯晓燕,焦蕴,储康康,黄海青,汤天宇,邹冰,杭跃跃,周振宇,陆祖宏. 高功能孤独症患儿胼胝体及额叶体积的磁共振研究[J]. 中国神经精神疾病杂志, 2011, 37(1) |
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| 作者姓名： | 张久平 洪珊珊 柯晓燕 焦蕴 储康康 黄海青 汤天宇 邹冰 杭跃跃 周振宇 陆祖宏 |
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| 作者单位： | 1. 南京医科大学附属脑科医院,南京,210029
2. 东南大学儿童发展与学习科学教育部重点实验室 |
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| 基金项目： | 江苏省自然科学基金项目(编号:BK2008082) |
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| 摘 要： | 目的探讨高功能孤独症(high functioning autism,HFA)患儿的胼胝体以及额叶体积是否异常。方法对17例6~14岁的HFA患儿(智商≥70)以及16名年龄、性别、智商等与患者组相匹配的健康学龄儿童进行T1加权三维容积磁共振成像。根据改良的Witelson范式将胼胝体划分为五个亚区,采用自编软件计算和比较两组被试胼胝体区及各个亚区的体积,应用个体脑结构地图集(Individual brain atlases using SPM,IBASPM)工具箱计算额叶体积。结果 HFA组与正常对照组相比额叶总体积及左侧额叶体积增大[(193.91±23.23)cm3vs(177.86±18.2)cm3,P=0.04;(96.08±11.89)cm3vs(87.52±9.14)cm3,P=0.03],而右侧额叶、胼胝体总体积及各亚区的体积差异均无统计学意义(P>0.05);HFA组胼胝体前三分之一部的体积与额叶总体积、右侧额叶体积呈正相关(r=0.51,P=0.04;r=0.50,P=0.04);未见HFA组中儿童孤独症评定量表评分与胼胝体及额叶的体积存在相关(P>0.05)。结论 HFA患儿的额叶体积增...
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| 关 键 词： | 高功能孤独症 磁共振成像 胼胝体 额叶体积 |
An magnetic resonance imaging study of the corpus callosum and frontal lobe volume in children with high functioning autism |
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| ZHANG Jiuping,HONG Shanshan,KE Xiaoyan,JIAO Yun,CHU Kangkang,HUANG Haiqing,TANG Tianyu,ZOU Bing,HANG Yueyue,ZHOU Zhenyu,LU Zuhong. An magnetic resonance imaging study of the corpus callosum and frontal lobe volume in children with high functioning autism[J]. Chinese Journal of Nervous and Mental Diseases, 2011, 37(1) |
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| Authors: | ZHANG Jiuping HONG Shanshan KE Xiaoyan JIAO Yun CHU Kangkang HUANG Haiqing TANG Tianyu ZOU Bing HANG Yueyue ZHOU Zhenyu LU Zuhong |
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| Affiliation: | ZHANG Jiuping,HONG Shanshan,KE Xiaoyan,JIAO Yun,CHU Kangkang,HUANG Haiqing,TANG Tianyu,ZOU Bing,HANG Yueyue,ZHOU Zhenyu,LU Zuhong.Child Mental Health Research Center of Nanjing Brain Hospital affiliated of Nanjing Medical University,Guangzhou Road 264#,Nanjing 210029.China. |
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| Abstract: | Objective To detect the volume differences in the total area,sub-regions of the corpus callosum and frontal lobe between patients with high functional autism(HFA) and normal children.Methods Structural magnetic resonance images were obtained in 17 HFA patients and 16-age,sex,intelligent quotient,height and weight matched normal controls.The corpus callosum was sub-divided into 5 sub-regions by Modified Witelson scheme.The volumes of the total area and sub-regions of corpus callosum were calculated by self-d... |
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| Keywords: | High functioning autism Magnetic resonance imaging Corpus callosum Frontal lobe Volume |
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