| 白细胞介素6基因多态性与动脉粥样硬化性脑梗死的关系 |
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| 引用本文： | 肖慧,谷文萍,梁静,唐春柳,董荣峥,龚娇娥,丁远英.白细胞介素6基因多态性与动脉粥样硬化性脑梗死的关系[J].中国神经精神疾病杂志,2011,37(1). |
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| 作者姓名： | 肖慧 谷文萍 梁静 唐春柳 董荣峥 龚娇娥 丁远英 |
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| 作者单位： | 中南大学湘雅医院神经内科,长沙,410008 |
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| 基金项目： | 教外司留学回国基金(编号:教外司留[2006]331号) |
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| 摘 要： | 目的探讨IL-6-572C/G基因多态性与中国湖南地区汉族人群动脉粥样硬化性脑梗死(atherosclerotic cerebral infarction,ACI)的关系。方法在湖南汉族人群中筛选199例脑梗死患者为脑梗死组,196名健康体检者为对照组,采用聚合酶链反应-限制性片段长度多态性(polymerase chain reaction-restriction fragment length poly-morphism,PCR-RFLP)方法测定IL-6-572C/G基因多态性。结果脑梗死组与对照组间比较,IL-6-572C/G基因型分布存在统计学差异(2=5.120,P<0.05),IL-6-572C/G基因C和G等位基因频率也存在统计学差异,(C和G等位基因频率,脑梗死组为0.741、0.259,对照组为0.816、0.184)(2=5.491,P<0.05)。G等位基因携带者发生脑梗死的风险是C等位基因的1.552倍(OR=1.552,95%CI:1.092-2.315)。结论 IL-6-572C/G基因多态性与ACI发病有关,可能是中国湖南地区汉族人群ACI发病的遗传易感基因。
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| 关 键 词： | 白细胞介素6-572C/G 脑梗死 基因多态性 |
The study on the association between interleukin-6 572C/G gene polymorphism and cerebral infarction |
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| XIAO Hui,GU Wenping,LIANG Jing,TANG Chunni,DONG Rongzhen,GONG Jiao'e,Ding Yuanying.The study on the association between interleukin-6 572C/G gene polymorphism and cerebral infarction[J].Chinese Journal of Nervous and Mental Diseases,2011,37(1). |
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| Authors: | XIAO Hui GU Wenping LIANG Jing TANG Chunni DONG Rongzhen GONG Jiao'e Ding Yuanying |
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| Institution: | XIAO Hui,GU Wenping,LIANG Jing,TANG Chunni,DONG Rongzhen,GONG Jiao'e,Ding Yuanying.Department of Neurology,XiangYa Hospital,Central South University,Hunan,Changsha,China,410008. |
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| Abstract: | Objective To investigate whether IL-6-572C/G polymorphism is associated with atherosclerotic cerebral infarction(ACI) in a Han population in Hunan Province.Methods The distributions of allele and genotype frequencies of 572C/G polymorphism of IL-6 gene were examined in 199 patients with ACI and 196 healthy controls using Polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP).Results There was significant difference in genotype of 572C/G polymorphism between ACI patients and controls(X2... |
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