| 宫颈癌组织中RRM1的表达及意义 |
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| 引用本文： | 刘爱华,王黎明.宫颈癌组织中RRM1的表达及意义[J].中国实用医药,2011,6(9):1-3. |
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| 作者姓名： | 刘爱华 王黎明 |
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| 作者单位： | 1. 山东省青岛大学医学院附属医院妇产科,266003
2. 蓬莱市人民医院妇产科 |
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| 摘 要： | 目的探讨RRM1在宫颈癌组织中的表达水平与宫颈癌发生、发展的关系。方法应用免疫组织化学方法检测RRM1蛋白在80例宫颈癌组织、30例宫颈上皮内瘤变和20例正常宫颈组织中的表达。结果 RRM1在正常宫颈组织、宫颈上皮内瘤变和宫颈癌组织中都有不同程度的表达,但宫颈癌组织中RRM1的表达(93.7%,75/80)明显高于宫颈内瘤变(46.7%,14/30)和正常宫颈组织(10.0%,2/20),且宫颈癌组织分化程度越低则RRM1的阳性率越高,表达强度越强(P<0.01);RRM1的表达与宫颈癌临床分期无关(P>0.05);不同组织类型的宫颈癌RRM1的表达差异无统计学意义(P>0.05);RRM1的阳性表达与有无淋巴结转移无关(P>0.05)。结论 RRM1在宫颈癌组织中的表达与宫颈癌组织分化的高低有关。RRM1在宫颈癌的发生发展中起重要作用,有望成为宫颈癌新的早期诊断指标。
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| 关 键 词： | 宫颈癌 宫颈上皮内瘤变 RRM1 免疫组织化学 |
Expression and significance of RRM1 in uterine cervical cancer tissue |
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| LIU Ai-hua,WANG Li-ming.Expression and significance of RRM1 in uterine cervical cancer tissue[J].China Practical Medical,2011,6(9):1-3. |
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| Authors: | LIU Ai-hua WANG Li-ming |
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| Institution: | LIU Ai-hua,WANG Li-ming.Department of Gynaecology and Obstetrics,The Medical School Hospital of Qingdao University,Qingdao,Shandong 266003,China |
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| Abstract: | Objective To study the expression of RRM1 in uterine cervical cancer tissue and explore the relationship with the development of uterine cervical cancer.Methods The expression of RRM1 was detected by immunohistochemistry staining in 80 specimens of cervical cancer,30 specimens of CIN and 20 specimens of normal cervical tissue.Results The expression of RRM1 was significantly higher in uterine cervical cancer tissue(93.7%,75/80)than that in CIN(46.7%,14/30)and normal cervical tissue(10.0%,2/20)(P<0.05).The mu... |
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| Keywords: | Uterine cervical cancer Cervical intraepithelial neoplasis RRM1 Immunohistochemistry |
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