| 川芎嗪对大鼠心肌缺血再灌注损伤细胞凋亡的影响 |
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| 引用本文： | 刘静,牛鹏武. 川芎嗪对大鼠心肌缺血再灌注损伤细胞凋亡的影响[J]. 中国实用医药, 2011, 6(2): 29-30 |
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| 作者姓名： | 刘静 牛鹏武 |
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| 作者单位： | 1. 沈阳市第九人民医院心内科,110024
2. 沈阳市铁西区中心医院急诊科 |
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| 摘 要： | 目的探讨川芎嗪对大鼠心肌缺血再灌注损伤时细胞凋亡的影响及可能的机制。方法雄性SD大鼠36只随机分三组:假手术组、模型组、川芎嗪治疗组,每组12只。用结扎大鼠左冠状动脉前降支法制备心肌缺血再灌注模型,测定再灌注前静脉注入川芎嗪对损伤大鼠心肌组织中MDA,SOD生成的影响;免疫组化法检测大鼠心肌细胞Bcl-2、Bax基因表达。结果①川芎嗪组能减少心肌组织中MDA生成,并明显提高缺血再灌注组织中SOD的活力;②川芎嗪组中bcl-2表达明显增多,平均灰度值明显下降,与模型组比较有显著差异(P>0.01),bax表达下降,但无统计学意义(P>0.05)。结论川芎嗪可能通过拮抗氧自由基、上调凋亡抑制基因bcl-2等作用,对心肌缺血再灌注损伤时细胞凋亡有一定的防治作用。
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| 关 键 词： | 川芎嗪 缺血再灌注损伤 自由基 心肌细胞凋亡 |
Protective effects of chuan xiong qin against ischemia/reperfusion injury in Rats |
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| LIU Jing,NIU Peng-wu. Protective effects of chuan xiong qin against ischemia/reperfusion injury in Rats[J]. China Practical Medical, 2011, 6(2): 29-30 |
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| Authors: | LIU Jing NIU Peng-wu |
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| Affiliation: | .Department of cardiology,the nineth people’s hospital of shenyang,Shenyang 110024,China |
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| Abstract: | Objective The objective of the present study is to investigate the Effects and mechanism of chuan xiong qin on cardiomyocyte apoptosis after ischemia reperfusion.Methods 36 male Sprague- Dauley rats were randomly divided into Three groups:sham operating group, ischemia reperfusion group, treatment group,which group had 12 rats. The left anterior descended(LAD)coronary artery was ligated to establish the ischemia/reperfusion heart model. The rats were injected chuan xiong qin before reperfusion. The concentr... |
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| Keywords: | Chuan xiong qin Ischemia-reperfusion injury Free adical Apoptosis |
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