| 芷冰鼻腔原位凝胶剂的质量评价 |
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| 引用本文： | 董芙蓉,刘莉,陈志良,刘强.芷冰鼻腔原位凝胶剂的质量评价[J].中国实验方剂学杂志,2011,17(4):19-22. |
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| 作者姓名： | 董芙蓉 刘莉 陈志良 刘强 |
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| 作者单位： | 1. 南方医科大学附属南方医院药学部,广州,510515
2. 南方医科大学中医药学院,广州,510515 |
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| 基金项目： | 广东省科技计划项目(2008B030301141) |
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| 摘 要： | 目的:评定芷冰鼻腔原位凝胶的质量,考察其初步稳定性。方法:采用HPLC测定方中欧前胡素和异欧前胡素的含量;采用黏度计测定凝胶黏度,采用位移法测定其黏附力;采用Valia-chien小池扩散法,考察凝胶的体外鼻黏膜渗透情况;采用体外溶出法,考察凝胶剂体外释药行为,采用pH计测定相变pH;采用离心、耐热耐寒、暴露试验和室温留样观察法对其稳定性进行初步研究。结果:凝胶剂有效成分含量稳定,黏度和黏附力、渗透系数、体外释放度、相变pH均符合2005年版《中国药典》中相关规定。初步稳定性试验表明凝胶剂耐热耐寒,性质稳定,可以长期存放。结论:芷冰鼻腔原位凝胶剂质量稳定,批间的差异较小。
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| 关 键 词： | 芷冰鼻腔原位凝胶剂 质量评价 稳定性 |
| 收稿时间： | 2010/8/25 0:00:00 |
Quality Evaluationa on Stability of ZhiBing In-Situ Gel Nasal-Cavity |
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| DONG Fu-rong,LIU Li,CHEN Zhi-liang and LIU Qiang.Quality Evaluationa on Stability of ZhiBing In-Situ Gel Nasal-Cavity[J].China Journal of Experimental Traditional Medical Formulae,2011,17(4):19-22. |
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| Authors: | DONG Fu-rong LIU Li CHEN Zhi-liang and LIU Qiang |
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| Institution: | DONG Fu-rong1,LIU Li2,CHEN Zhi-liang1,LIU Qiang2(1.Southern Medical University,College of Traditional Chinese Medicine,Guangzhou 510515,China,2.Department of Pharmacy,Nanfang Hospital Affiliated to Southern Medical University,China) |
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| Abstract: | Objective:To evaluate the quality and study the stability of Zhibing in-situ gel nasal-cavity.Method:High performance liquid chromatography(HPLC) was used to determine the content of imperatorin and isoimperatorin.Viscometer was used to determine the viscocity of gel.Displacement method was used to determine the adhesive force of gel.Valia-chien diffusion method was used to study the membrane permeation characteristics in vitro.In vitro dissolution method was used to study the in vitro release characteristi... |
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| Keywords: | Zhibing in-situ gel nasal-cavity quality evaluation stability |
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