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| 有氧运动对高脂膳食诱导的胰岛素抵抗小鼠骨骼肌细胞胰岛素受体底物1及其丝氨酸磷酸化活性的影响 | |
| 引用本文： | 杨风英,牛燕媚,刘彦辉,王家仲,傅力.有氧运动对高脂膳食诱导的胰岛素抵抗小鼠骨骼肌细胞胰岛素受体底物1及其丝氨酸磷酸化活性的影响[J].中国运动医学杂志,2011,30(1):36-41. |
| 作者姓名： | 杨风英 牛燕媚 刘彦辉 王家仲 傅力 |
| 作者单位： | 1. 天津医科大学康复与运动医学系,天津,300070 2. 天津体育学院健康与运动科学系 3. 天津医科大学康复与运动医学系,天津,300070;天津体育学院健康与运动科学系 |
| 基金项目： | 国家自然科学基金(30871213); 天津市应用基础及前沿技术重点研究计划(09JCZDJC17400)共同资助 |
| 摘 要： | 目的:探讨有氧运动对高脂膳食诱导胰岛素抵抗(insulin resistance,IR)小鼠骨骼肌细胞胰岛素受体底物1(insulin receptor substrates-1,IRS1)及其丝氨酸磷酸化活性的影响,以及结节性硬化复合物蛋白2(tuberous sclerosis complex-2,TSC2)在此过... |
| 关 键 词： | 胰岛素抵抗 有氧运动 胰岛素受体底物1 结节性硬化复合物蛋白2 |
Effects of Aerobic Exercise on the Insulin Receptor Substrates-1 and Its Serine Phosphorylation Activity in Mice with Insulin Resistance |
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| Yang Fengying,Niu Yanmei,Liu Yanhui,Wang Jiazhong,Fu Li.Effects of Aerobic Exercise on the Insulin Receptor Substrates-1 and Its Serine Phosphorylation Activity in Mice with Insulin Resistance[J].Chinese Journal of Sports Medicine,2011,30(1):36-41. | |
| Authors: | Yang Fengying Niu Yanmei Liu Yanhui Wang Jiazhong Fu Li |
| Institution: | Yang Fengying1,Niu Yanmei1,Liu Yanhui2,Wang Jiazhong1,Fu Li1,2 1 Department of Rehabilitation and Sports Medicine,Tianjin Medical University,Tianjin,China 300070 2 Department of Health and Exercise Science,Tianjin Institute of Physical Education,China 300381 |
| Abstract: | Objective To study the effects of aerobic exercise on the insulin receptor substrates-1(IRS1)and its serine phosphorylation activity in mice with high fat diet induced-insulin resistance(IR)and to explore the possible role of tuberous sclerosis complex-2(TSC2)during this process.Methods 4-week old C57BL/6 mice were fed with high fat diet for 10 weeks to induce IR.The IR mice were randomly divided into control group(HC,n=20)and exercise group(HE,n=20).All mice were continually fed with high fat diet for anot... |
| Keywords: | insulin resistance aerobic exercise IRS1 TSC2 |
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