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| 恩氟烷镇痛作用与脊髓5-HT1A受体的关系 | |
| 引用本文： | 王芬,严姝姝,刘晶晶,田艳艳,宋歌,杨晓琳,陈默,邢甜,马涛,袁力勇.恩氟烷镇痛作用与脊髓5-HT1A受体的关系[J].江苏医药,2011,37(1). |
| 作者姓名： | 王芬 严姝姝 刘晶晶 田艳艳 宋歌 杨晓琳 陈默 邢甜 马涛 袁力勇 |
| 作者单位： | 1. 徐州医学院麻醉学院,221002 2. 徐州医学院麻醉药理学教研室 3. 宁波市妇女儿童医院麻醉科 |
| 基金项目： | 宁波市自然科学基金资助项目(No2009A610140); 江苏省高校自然科学基础研究资助项目(No09KJB320019) |
| 摘 要： | 目的探讨恩氟烷镇痛作用与脊髓5-羟色胺受体1A(5-HT1AR)之间的关系。方法腹腔注射恩氟烷建立镇痛模型,用甩尾法、热板法和扭体法分别观察鞘内注射5-HT1AR特异性拮抗剂p-MPPF对小鼠甩尾潜伏期(TFL)、热板法痛阈(HPPT)和扭体次数(WTs)的影响。结果腹腔注射恩氟烷可产生镇痛作用(P<0.05);单用p-MPPF 4μg/只或8μg/只对小鼠TFL、HPPT和WTs均无明显影响(P>0.05);两个剂量的p-MPPF均能使恩氟烷镇痛小鼠的TFL、HPPT缩短和WTs增加(P<0.05)。结论恩氟烷镇痛作用与脊髓5-HT1AR密切相关。 |
| 关 键 词： | 5-羟色胺1A受体 p-MPPF 恩氟烷 |
Relationship between the analgesic effect of enflurane and the 5-HT1A receptors in the spinal cord of mice |
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| WANG Fen,YAN Shushu,LIU Jingjing et al.School of Anesthesiology,Xuzhou Medical College,Xuzhou ,CHINA.Relationship between the analgesic effect of enflurane and the 5-HT1A receptors in the spinal cord of mice[J].Jiangsu Medical Journal,2011,37(1). | |
| Authors: | WANG Fen YAN Shushu LIU Jingjing School of Anesthesiology Xuzhou Medical College Xuzhou CHINA |
| Institution: | WANG Fen,YAN Shushu,LIU Jingjing et al.School of Anesthesiology,Xuzhou Medical College,Xuzhou 221002,CHINA |
| Abstract: | Objective To investigate the relationship between the analgesic effect of enflurane and 5-HT1A receptor in the spinal cord of mice.Methods After the analgesic mice models were established by intraperitoneal injection of enflurane,the influences of p-MPPF(a specific antagonist of 5-HT1A receptors) intrathecal injection on the changes of tail-flick latency(TFL) in hot water tail-flick test,pain threshold in hot-plate test(HPPT) in hot-plate test and the writhing times(WTs) in acetic-induced writhing test were... |
| Keywords: | 5-HT1AR p-MPPF Enflurane |
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