Role of Thy-1,2+ cells in the regulation of hemopoiesis during severe hypoxia

We studied the state of the bone marrow Thy-1,2⁺ cell pool under conditions of severe hypoxia. T cell mechanisms of hemopoiesis regulation are preserved under conditions of severe oxygen deficiency due to changes in functional properties of Thy-1,2⁺ cells. We revealed an indirect (mediated through cooperation with adherent myelokaryocytes) stimulating effect of Thy-1,2⁺ cells on erythroid precursors as well as direct and indirect feeder effects of these cells on granulocyte-monocyte precursors. __________ Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 143, No. 1, pp. 23–27, January, 2007