| Survivin在宫颈鳞癌中的表达及其意义 |
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| 引用本文： | 王修珍,邓海珍,顾永平. Survivin在宫颈鳞癌中的表达及其意义[J]. 苏州大学学报(自然科学版), 2005, 25(5): 875-876 |
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| 作者姓名： | 王修珍 邓海珍 顾永平 |
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| 作者单位： | 苏州大学医学院基础医学系病理学教研室,江苏苏州215007 |
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| 摘 要： | 目的研究Survivin在宫颈鳞癌组织中的表达及其意义。方法采用免疫组化S-P法对53例不同分化程度的鳞癌组织及10例慢性宫颈炎组织进行Survivin检测。结果10例慢性宫颈炎组织中未发现Survivin阳性表达，53例宫颈鳞癌中Survivin阳性表达率为54．7％（29／53），阳性表达的Survivin主要定位于肿瘤组织的细胞浆，偶见于细胞核。结论宫颈鳞癌组Survivin阳性表达显著高于慢性宫颈炎组，并与富颈鳞癌的分化程度有关，提示Survivin参与了宫颈癌的发生和发展过程。
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| 关 键 词： | 鳞癌 宫颈 Survivin 免疫组织化学 宫颈鳞癌 其意义 阳性表达率 免疫组化S-P法 慢性宫颈炎 鳞癌组织 |
| 文章编号： | 1673-0399(2005)05-0875-02 |
| 收稿时间： | 2005-03-31 |
| 修稿时间： | 2005-03-31 |
Expression and Significance of Survivin in Cervical Squamous Cell Carcinoma |
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| WANG Xiu-zhen,DENG Hai-zhen,GU Yong-ping. Expression and Significance of Survivin in Cervical Squamous Cell Carcinoma[J]. Suzhou University Journal of Medical Science, 2005, 25(5): 875-876 |
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| Authors: | WANG Xiu-zhen DENG Hai-zhen GU Yong-ping |
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| Abstract: | Objective To study the expression and significance of survivin in cervical squamous cell carcinoma.Methods S-P immunohistochemical method was adopted to examine the expression of survivin in 53 specimens of cervical squamous cell carcinoma and in 10 specimens of chronic cervicitis.Results Expressions of survivin in chronic cervicitis were negative.The positivity rate of survivin expressions in cervical squamous cell carcinoma was 54.7%(29/53).The positive expression of survivin mainly located in cell cytoplasm,fewer in nucleus.Conclusion The positive expression of survivin in ceivical squamous cell carcinoma group is higher than that in the chronic civicitis group and positive expressions of survivin in cervical squamous cell carcinoma relate to the degree of differentiation.The results suggest the survivin may participate in developing and progressing in squamous cell carcinoma of cervix. |
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| Keywords: | survivin squamous cell carcinoma cervix immunohistochemistry |
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