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| 经硬脑膜电刺激对视皮层神经活动影响的仿真研究 | |
| 引用本文： | 夏楠,侯文生,章毅,郑小林,吴小鹰,阴正勤,JIANGYingtao.经硬脑膜电刺激对视皮层神经活动影响的仿真研究[J].中国生物医学工程学报,2011(5). |
| 作者姓名： | 夏楠 侯文生 章毅 郑小林 吴小鹰 阴正勤 JIANGYingtao |
| 作者单位： | 1. 重庆大学生物工程学院,重庆,400044 2. 第三军医大学西南医院眼科,重庆,400038 3. Department of Electrical and Computer Engineering, University of Nevada, Las Vegas, NV 89154, USA |
| 基金项目： | 国家高技术研究发展(863)计划，国家自然科学基金 |
| 摘 要： | 经硬脑膜对视皮层电刺激为视觉功能修复提供了一种新的技术思路.前期的仿真工作利用激活函数定性研究了经硬脑膜电刺激对视皮层的作用效果,本研究在原有模型基础上引入神经无模型,定量研究不同刺激波形及参数对电极作用范围的影响.该方法将已建立的神经元模型耦合到视皮层区域有限元模型中,利用傅里叶-有限元方法分别计算双脉冲、指数脉冲和正弦波刺激下视皮层区域模型内的场电位,将电位加载到神经元模型上,观察神经元是否发生兴奋,以神经元区域兴奋个数判定电极的作用范围.仿真结果表明,该方法能较好的表达刺激的响应范围:不同刺激波形及参数引起的神经元区域兴奋数量不同,且解剖结构会影响刺激效果.所得结果对实验具有一定指导意义. |
| 关 键 词： | 硬脑膜 视皮层 神经计算 神经电刺激 |
Simulation Study of the Effect on Visual Cortex Neural Activation during Epidural Electrical Stimulation |
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| XIA Nan,HOU Wen-Sheng,ZHANG Yi,ZHENG Xiao-Lin,WU Xiao-Ying,YIN Zheng-Qin,JIANGYingtao.Simulation Study of the Effect on Visual Cortex Neural Activation during Epidural Electrical Stimulation[J].Chinese Journal of Biomedical Engineering,2011(5). | |
| Authors: | XIA Nan HOU Wen-Sheng ZHANG Yi ZHENG Xiao-Lin WU Xiao-Ying YIN Zheng-Qin JIANGYingtao |
| Institution: | XIA Nan1 HOU Wen-Sheng1* ZHANG Yi1 ZHENG Xiao-Lin1 WU Xiao-Ying1 YIN Zheng-Qin2 JIANG Ying-Tao3 1(Bioengineering College of Chongqing University,Chongqing 400044,China) 2(Department of Ophthalmology,Third Military Medical University,Chongqing 400038,China) 3(Department of Electrical and Computer Engineering,University of Nevada,Las Vegas,NV 89154,USA) |
| Abstract: | The epidural electrical stimulation applied on the visual cortex is a new tachnical idea for vision rehabilitation.Previous researches have shown that the effects on visual cortex during epidural electrical stimulation can be qualitatively described by using the activating function,but this method can not accurately describe the scope of the electrode.In this paper we introduced neuron model into original model and quantify the effect of different stimulation waveforms and parameters on the scope of the ele... |
| Keywords: | dura mater visual cortex neural computation electric nerve stimulation |
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