| 多节孢属Nodulisporium sp.真菌中一个新的生物碱类化合物 |
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| 引用本文： | 王高乾,赵琴,郑启昌,陈国栋,何蓉蓉,郭良栋,姚新生,高昊.多节孢属Nodulisporium sp.真菌中一个新的生物碱类化合物[J].中国中药杂志,2015,40(13):2598-2601. |
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| 作者姓名： | 王高乾 赵琴 郑启昌 陈国栋 何蓉蓉 郭良栋 姚新生 高昊 |
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| 作者单位： | 暨南大学 药学院 中药及天然药物研究所, 广东 广州 510632,暨南大学 药学院 中药及天然药物研究所, 广东 广州 510632,暨南大学 药学院 中药及天然药物研究所, 广东 广州 510632,暨南大学 药学院 中药及天然药物研究所, 广东 广州 510632,暨南大学 药学院 中药及天然药物研究所, 广东 广州 510632,中国科学院 微生物研究所 真菌学国家重点实验室, 北京 100190,暨南大学 药学院 中药及天然药物研究所, 广东 广州 510632,暨南大学 药学院 中药及天然药物研究所, 广东 广州 510632 |
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| 基金项目： | 国家自然科学基金项目(81422054) |
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| 摘 要： | 多节孢属真菌代谢产物结构多样。该研究通过正相硅胶色谱、反相制备液相色谱等方法,从一株多节孢属真菌的固体发酵提取物中分离鉴定4个代谢产物,包括1个新化合物;根据理化性质和波谱数据,分别鉴定为2-羟基-1,1-二甲基-1,2,3,9-四氢-4H-咔唑-4-酮(1)、酪醇(2)、羟基酪醇(3)和羟基酪醇乙酸酯(4),其中1为新化合物。
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| 关 键 词： | 多节孢属真菌 代谢产物 生物碱 |
| 收稿时间： | 2015/6/25 0:00:00 |
A new alkaloid from Nodulisporium sp. |
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| WANG Gao-qian,ZHAO Qin,ZHENG Qi-chang,CHEN Guo-dong,HE Rong-rong,GUO Liang-dong,YAO Xin-sheng and GAO Hao.A new alkaloid from Nodulisporium sp.[J].China Journal of Chinese Materia Medica,2015,40(13):2598-2601. |
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| Authors: | WANG Gao-qian ZHAO Qin ZHENG Qi-chang CHEN Guo-dong HE Rong-rong GUO Liang-dong YAO Xin-sheng and GAO Hao |
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| Institution: | Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Ji'nan University, Guangzhou 510632, China,Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Ji'nan University, Guangzhou 510632, China,Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Ji'nan University, Guangzhou 510632, China,Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Ji'nan University, Guangzhou 510632, China,Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Ji'nan University, Guangzhou 510632, China,State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, China,Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Ji'nan University, Guangzhou 510632, China and Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Ji'nan University, Guangzhou 510632, China |
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| Abstract: | he genus Nodulisporium, is known to produce secondary metabolites with structural diversity. A new alkaloid, 2-hydroxy-1,1-dimethyl-1,2,3,9-tetrahydro-4H-carbazol-4-one(1), was isolated from the extract of a fungal strain Nodulisporiumsp. fermented with rice, together with three known phenols, tyrosol(2), hydroxytyrosol(3), and hydroxytyrosol acetate(4). Their structures were identified by detailed spectroscopic analyses. |
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| Keywords: | Nodulisporium sp secondary metabolites alkaloid |
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