| 基于网络方剂学的小青龙汤类方功效物质组研究 |
| |
| 引用本文： | 范骁辉,肖舜,艾妮,廖杰,程翼宇.基于网络方剂学的小青龙汤类方功效物质组研究[J].中国中药杂志,2015,40(13):2634-2638. |
| |
| 作者姓名： | 范骁辉 肖舜 艾妮 廖杰 程翼宇 |
| |
| 作者单位： | 浙江大学 药学院 中药科学与工程学系, 浙江 杭州 310058,浙江大学 药学院 中药科学与工程学系, 浙江 杭州 310058,浙江大学 药学院 中药科学与工程学系, 浙江 杭州 310058,浙江大学 药学院 中药科学与工程学系, 浙江 杭州 310058,浙江大学 药学院 中药科学与工程学系, 浙江 杭州 310058 |
| |
| 基金项目： | 国家重点基础研究发展计划(973)项目(2012CB5184) |
| |
| 摘 要： | 类方集历代名医应用之精华,是中医原创思维的重要载体。该文以小青龙汤、麻黄杏仁石膏甘草汤、麻黄附子汤、厚朴麻黄汤和大青龙汤等5个小青龙汤类方为例,采用网络方剂学研究策略,在系统的化学组成辨识基础上,通过知识关联网络构建及分析,探讨其化学组成与主治异同之间的关联,初步揭示了小青龙汤类方在宣肺平喘、助阳解表方面的功效物质组。这一研究实例表明,网络方剂学可为诠释仲景方组方的科学内涵提供新的研究视角。
|
| 关 键 词： | 方剂学 网络药理学 网络方剂学 类方 仲景方 功效物质组 |
| 收稿时间： | 2015/6/20 0:00:00 |
Dissecting functional chemome of Xiaoqinglong decoction analogous formulae using network formulaology approach |
| |
| FAN Xiao-hui,XIAO Shun,AI Ni,LIAO Jie and CHENG Yi-yu.Dissecting functional chemome of Xiaoqinglong decoction analogous formulae using network formulaology approach[J].China Journal of Chinese Materia Medica,2015,40(13):2634-2638. |
| |
| Authors: | FAN Xiao-hui XIAO Shun AI Ni LIAO Jie and CHENG Yi-yu |
| |
| Institution: | Department of Chinese Medicine Science& Engineering, Zhejiang University, Hangzhou 310058, China,Department of Chinese Medicine Science& Engineering, Zhejiang University, Hangzhou 310058, China,Department of Chinese Medicine Science& Engineering, Zhejiang University, Hangzhou 310058, China,Department of Chinese Medicine Science& Engineering, Zhejiang University, Hangzhou 310058, China and Department of Chinese Medicine Science& Engineering, Zhejiang University, Hangzhou 310058, China |
| |
| Abstract: | Analogous formulae (AF) refer to a set of traditional Chinese medicine (TCM) formulae sharing similar herbs and/or indications. Dissecting functional chemome of analogous formulae could enhance the understanding of the intrinsic nature of TCM. In this study, taking 5 Xiaoqinglong decoction analogous formulae (XQL AF) including Xiaoqinglong decoction, Mahuang Xingren Shigao Gancao decoction, Mahuang Fuzi decoction, Houpu Mahuang decoction and Daqinglong decoction as example, we systematically investigated the relationship between compounds and indications using network formulaology approach. The functional chemome of XQL AF were revealed by network analysis and molecular docking. This successful application in XQL AF suggests network formulaology could be a useful tool for AF-related research and therefore provide a new way to discover the scientific foundation of Zhang Zhongjing's herbal formulae. |
| |
| Keywords: | formulaology network pharmacology network formulaology analogous formulae Zhang Zhongjing's herbal formulae functional chemome |
|
|
