| 促性腺激素释放激素拮抗剂的3种用药方案在体外受精-胚胎移植中的有效性对比 |
| |
| 引用本文： | 段金良,刘英,曾琼芳,蒋元华,黄雅丹. 促性腺激素释放激素拮抗剂的3种用药方案在体外受精-胚胎移植中的有效性对比[J]. 实用妇产科杂志, 2010, 26(3) |
| |
| 作者姓名： | 段金良 刘英 曾琼芳 蒋元华 黄雅丹 |
| |
| 作者单位： | 解放军一八一医院,广西,桂林,541002 |
| |
| 摘 要： | 目的:探讨一种适合中国人群、有效的促性腺激素释放激素(GnRH)拮抗剂用药方案.方法:选择进行体外受精·胚胎移植(IVF-ET)治疗的患者102例共114周期,根据拮抗剂使用的不同方法分为3组.A组:从卵巢刺激第6天开始加用GnRH拮抗剂(Cetrotide,Serono),0.25 mg/d,至绒促性素(HCG)注射日.B组:当主导卵泡直径达12～14 mm时开始注射拮抗剂,0.25 mg/a,至HCG日.C组:当主导卵泡达14 mm时,一次性注射拮抗剂0.75 mg.结果:3组患者平均促性腺激素(Gn)用量及天数、各时段LH水平、获卵数、各型卵-冠-丘复合物数、受精率、卵裂率、着床率、临床妊娠率、流产率差异均无统计学意义(P>0.05),均未发生过早的LH峰及提前排卵情况,均无中、重度卵巢刺激综合征(OHSS)发生,但拮抗剂用量A组与B组、A组与C组差异有统计学意义(P<0.01),B组与C组差异无统计学意义(P>0.05).结论:在IVF卵巢刺激中,当主导卵泡直径达14 mm时一次性注射拮抗剂0.75 mg即可有效抑制LH峰,获得满意的临床效果.
|
| 关 键 词： | 体外受精-胚胎移植 促性腺激素释放激素拮抗剂 临床妊娠率 |
Comparison of Effectiveness of Three Regimens of GnRH Antagonist in In-vitro Fertilization and Embryo Transfer |
| |
| DUAN Jinliang,LIU Ying,ZENG Qiongfang,et al. Comparison of Effectiveness of Three Regimens of GnRH Antagonist in In-vitro Fertilization and Embryo Transfer[J]. Journal of Practical Obstetrics and Gynecology, 2010, 26(3) |
| |
| Authors: | DUAN Jinliang LIU Ying ZENG Qiongfang et al |
| |
| Affiliation: | DUAN Jinliang,LIU Ying,ZENG Qiongfang,et al(The PLA 181 Hospital,Guilin Guangxi 541002,China) |
| |
| Abstract: | Objective:An effective regimen of GnRH antagonist used in in-vitro fertilization and embryo transfer (IVF-ET) in Chinese population was explored.Methods:114 cycles of IVF-ET in 102 infertile couples were recruited and divided into 3 groups according to different regimens of antagonist. In group A, the antagonist (Cetrotide, Serono) was used from day 6 of ovarian stimulation to the day of HCG injection in the dose of 0.25 mg per day. In group B, the same dose antagonist was administered when the diameters of... |
| |
| Keywords: | In-vitro fertilization and embryo transfer GnRH antagonist Clinical pregnancy rate |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
