紫杉醇与顺铂联合治疗晚期非小细胞肺癌疗效观察(附52例临床报告)

目的：观察及评价紫杉醇联合顺铂化疗非小细胞肺癌的疗效和不良反应。方法：52例初治晚期非小细胞肺癌患者应用紫杉醇135mg/m^2,iv,dl；顺铂30mg/m^2,iv,dl,2,3。每21天一周期，2－3周一疗程。应用抗过敏药物预防紫杉醇的不良反应，还原型谷胱甘肽加小剂量水化预防顺铂引起的肾毒性。结果：完全缓解（CR）4例，部分缓解（PR）15例，稳定（NC）22例，进展（PD）11例，总有效率36．5％；中位生存时间38周，1年生存率43％。结论：紫杉醇与顺铂联合为治疗晚期非小细胞肺癌疗效较佳的方案，抗过敏药物及还原型谷胱甘肽可有效预防该方案的不良反应。

Combination Chemotherapy of Paclitaxel and Cisplatin in the Treatment of Advanced Non-Small Cell Lung Cancer -A Report of 52 Cases

Objective:To study the efficacy of paclitaxel plus cisplatin in the treatment of advanced non-small cell lung cancer(NSCLC).Methods:Fifty-two patients with advanced non-small cell lung cancer untreated previously were treated by combination chemotherapy of pa-clitaxel135mg /m 2 iv d1and cisplatin30mg /m 2 iv d1,2,3and it was repeated every21days.Results:There were CR4cases,PR15cases,NC22cases and PD11cases.The overall re-sponse rate was36.5%,the median survival time was38weeks and one year survival rate was43%.Conclusion:The combination chemotherapy of paclitaxel and cisplatin is a good regimen for the treatment of advanced NSCLC.