| 糖尿病人肝脏的超微结构研究 |
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| 引用本文： | 秦映芬,冼苏,韦敏怡,罗佐杰,陈青云,王乃尊. 糖尿病人肝脏的超微结构研究[J]. 临床肝胆病杂志, 2000, 16(4): 241-243 |
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| 作者姓名： | 秦映芬 冼苏 韦敏怡 罗佐杰 陈青云 王乃尊 |
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| 作者单位： | 1. 广西医科大学一附院内分泌科,广西,南宁,530021
2. 广西医科大学一附院病理科,广西,南宁,530021 |
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| 摘 要： | 研究糖尿病（ＤＭ）人肝脏的超微结构变化。对２０例ＤＭ患者行肝穿活检,所取标本行光、电镜观察。光镜下见核内糖原空洞、脂肪变性及间质纤维化。电镜下见：核内糖原颗粒;胞浆糖原颗粒增多;粗面内质网（ＲＥＲ）脱粒;滑面内质网（ＳＥＲ）扩张;线粒体（Ｍｉ）肿胀,嵴紊乱,结构消失或电子密度增高,结构不清;脂肪变性;间质纤维化。ＤＭ肝超微结构改变中最具特征性的是核内糖原颗粒。
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| 关 键 词： | 糖尿病 肝脏 超微结构 RER脱粒 SER扩张 |
| 文章编号： | 1001-5256(2000)04-0241-03 |
| 修稿时间： | 1999-09-02 |
Changes of hepatic ultrastructure in patients with diabetes mellitus |
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| QIN Ying fen,XIAN Su,WEI Min yi,et al.. Changes of hepatic ultrastructure in patients with diabetes mellitus[J]. Chinese Journal of Clinical Hepatology, 2000, 16(4): 241-243 |
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| Authors: | QIN Ying fen XIAN Su WEI Min yi et al. |
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| Affiliation: | QIN Ying fen,XIAN Su,WEI Min yi,et al.Department of Endocrinology,First hospital affiliated to Guang Xi Medical University,530021 |
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| Abstract: | Objective:To study the changes of hepatic ultrastructure in patients with diabetes mellitus.Methods:Liver biopsy and pathological examination were carried out in 20 diabetes mellitus patients.Result Under light microscope,It showed that nuclear glycogen cavity,fatty degeneration and interstitial fibrosis.Whereas electron microscope:nuclear glycogen granules;glycogen granules in cytoplasm increase;rough endoplasmic reticulum degranulation;smooth endoplasmic reticulum expansion;mitochondrial swelling,crista disorder or electron density increase;fatty degeneration;interstitial fibrosis.Conclusion:The most characteristic change of hepatic ultrastructure is nuclear glycogen granules in diabetes mellitus. |
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| Keywords: | Diabetes mellitus Liver Ultrastructureh |
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