| 益肾调督针法对脑缺血再灌注大鼠P-selectin mRNA和蛋白表达的影响 |
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| 引用本文： | 庞勇,畅英才,吴刚,冯卓,陈丽容. 益肾调督针法对脑缺血再灌注大鼠P-selectin mRNA和蛋白表达的影响[J]. 针灸临床杂志, 2010, 26(8) |
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| 作者姓名： | 庞勇 畅英才 吴刚 冯卓 陈丽容 |
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| 作者单位： | 广西中医学院第一附属医院,广西,南宁,530001 |
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| 基金项目： | 广西区科技厅自然科学基金 |
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| 摘 要： | 目的:通过观察益肾调督针法对脑缺血再灌注大鼠脑内P-selectin mRNA和蛋白表达的影响,探讨益肾调督针法治疗缺血性脑损伤的机制。方法:采用大鼠局灶性脑缺血再灌注模型,应用原位杂交及免疫组化方法观察脑缺血再灌注时P-selectin mRNA和蛋白表达的变化,以及针刺对其影响。结果:正常组和假手术组大鼠P-selectin mRNA和蛋白在皮质区未见表达,脑缺血再灌注后12 h P-selectin mRNA和蛋白表达增强(P<0.05),针刺可明显抑制脑缺血区皮质P-selectin mRNA和蛋白的表达(P<0.05或0.01)。结论:益肾调督针法对缺血性脑损伤的保护作用机制与针刺抑制脑内P-selectin mRNA的表达从而减少P-selectin蛋白的合成有关。
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| 关 键 词： | 益肾调督 脑缺血再灌注 P-选择素 |
Study on Effects of Yishen Tiaodu Acupuncture Manipulation on the Expression of P-selectin-mRNA and Protein in Cerebral Ischemia-reperfusion Rats |
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| PANG Yong,CHANG Ying-cai,WU Gang,FENG Zhuo,CHEN Li-rong. Study on Effects of Yishen Tiaodu Acupuncture Manipulation on the Expression of P-selectin-mRNA and Protein in Cerebral Ischemia-reperfusion Rats[J]. Journal of Clinical Acupuncture and Moxibustion, 2010, 26(8) |
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| Authors: | PANG Yong CHANG Ying-cai WU Gang FENG Zhuo CHEN Li-rong |
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| Affiliation: | PANG Yong; CHANG Ying-cai; WU Gang; FENG Zhuo; CHEN Li-rong(The First Affiliated Hospitai of Guangxi College of Chinese Medicine; Nanning 530001; China); |
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| Abstract: | Objective:This study was designed to observe the effect of Yishen Tiaodu acupuncture manipulation on the expression of p-selectin mRNA and protein in cerebral ischemia-reperfusion rats and to further investigate the protective mechanism of Yishen Tiaodu acupuncture manipulation against ischemic brain damage from the angle of molecule in order to reveal deeply the mechanism of acupuncture treatment on cerebral ischemia.Methods:With the randomized controlled design and a random number table,Wistar rats were d... |
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| Keywords: | Cerebral ischemi Reperfusion injury Yishen Tiaodu Acu-therapy p-selectin |
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