细胞角质片段21-1、神经元特异性烯醇化酶在肺癌早期诊断中应用价值的探讨

目的　评价肿瘤标记物细胞角质片段 2 1 1(CYFRA2 1 1)、神经元特异性烯醇化酶(NSE)对肺癌早期诊断的价值。方法　将 3 0例肺癌患者分为非小细胞性肺癌组 (NSCLC)和小细胞性肺癌组 (SCLC) ,良性疾病患者为对照组。所有患者均经支气管镜检查进行患侧和健侧肺泡灌洗 ,收集肺泡灌洗液 (BALF) ,同时采静脉血 ,按放射免疫方法 (RIA)检测CYFRA2 1 1、NSE。结果　CYFRA2 1 1水平在NSCLC中明显高于SCLC和良性疾病患者。NSE则在SCLC中显著高于NSCLC和良性疾病组。各组BALF中CYFRA2 1 1、NSE水平均以患侧增高明显 (P <0 .0 5或0 .0 1) ,CYFRA2 1 1、NSE联合检测与各单项指标相比 ,正确率提高 ,以患侧BALF联合检测方法最优。结论　联合检测患侧BALF中CYFRA2 1 1、NSE的含量诊断肺癌的阳性率最高 ,准确性达97.14 %。

Evaluate the diagnostic performance of the tumor marker CYFRA21-1 and NSE in the lung cancer

Objective To evaluate the diagnostic performance of the tumor marker CYFRA21 1 and NSE in the lung cancer.Methods All patients divided into non small cell lung cancer group and small cell lung cancer group and benign lung disease as control group.BALF were collected from the both sides of lung in all subjects and venous sample were collected at the same time.The concentration of CYFRA21 1 and NSE were determined using RIA method.Results The CYFRA21 1 level in BALF and venous in the group with NSCLS was significantly higher than the group with SCLS and benign lung disease.The NSE level in BALF and venous in the group with SCLC was significantly higher than in the group with NSCLS and benign lung disease.The CYFRA21 1 and NSE concentration from the unhealthy lung side increased more significantly than from healthy side, and also their levels were in negative correlation with life time.The accuracy increased when combining the assay of CYFRA21 1 and NSE compared with the single parameter.The way of combining CYFRA21 1 and NSE from the unhealthy lung side is best.Conclusion The sensitivity is highest to the diagnosis of lung cancer when combining CYFRA21 1 and NSE in BALF from the unhealthy lung side,and its accuracy is 97.14%. [