伪麻黄碱水杨酸对小鼠中枢作用的研究

目的 了解伪麻黄碱水杨酸对小鼠中枢神经系统的作用。方法 采用行为药理学实验观察伪麻黄碱水杨酸对小鼠一般行为、自主活动、对戊巴比妥钠诱导睡眠潜伏期、睡眠持续时间以及戊四氮、烟碱和印防己毒素诱导惊厥作用的影响。结果 12．5、25．0、50．0、100．0mg／kg伪麻黄碱水杨酸腹腔注射后，小鼠外观行为表现为兴奋，但自主活动被抑制；以上4个剂量的伪麻黄碱水杨酸可显著抑制戊巴比妥钠诱导的催眠作用；100．0mg／kg伪麻黄碱水杨酸对戊四氮、烟碱及印防己毒素诱导的惊厥具有协同作用。结论 伪麻黄碱水杨酸对小鼠中枢具有兴奋作用。

Pharmacological Action of Pseudoephedrine Salicylate on the Central Nervous System of Mice

Objective To study the action of pseudoephedrine salicylate on the central nervous system of mice. Methods Following the administration of pseudoephedrine salicylate at various dose levels and schedules, the alterations in general behavior and autonomic activities of the mice were recorded using photoelectric counter Type GJ-1, the changes in hypnotic action indices (sleep latency, sleep-lasting time) for the mice placed on pentobarbital in advance were observed, and the muscular clonic spasm of forefoot and neck muscles as well as the deaths from convulsions induced by previously given pentylenetrazol, nicotin and picrotoxin were observed and recorded respectively. Results Pseudoephedrine salicylate (12.5,25.0,50.0,100.0 mg/kg) administrated ip significantly inhibited the autonomic activities and the hypnotic action induced by previously given pentobarbital. Pseudoephedrine salicylate (100.0 mg/kg ) given ip was noted to have synergistic effect on convulsions of the mice previously given pentylenetrazol and picrotoxin at subthreshold doses respectively, but no synergistic effect of pseudoephedrine salicylate (100 mg/kg) and nicotin (at subthreshold dose 0.018 mg/kg) was observed. Conclusion Pseudoephedrine salicylate has excited effect on the central nervous system of mice.