三种麻醉方法在巴马小型猪失血性休克实验中的麻醉效果比较

目的比较3种麻醉方法在巴马小型猪失血性休克（HS）实验中的麻醉效果，获取适宜巴马小型猪麻醉的最佳方案。方法巴马小型猪24头，随机分为氯胺酮肌内注射组（A组），异丙酚静脉注射组（B组），异丙酚静脉与七氟烷吸入复合麻醉组（c组），每组8头。分别于麻醉前（T0）、诱导后（T1）、置管后（T2）、HS即刻（T3）、HS后30min（T4）、复苏时（T5）、复苏后30min（T6）及实验结束拔管后10min（T7），观察并记录各组猪的心率（HR）、平均动脉压（MAP）、鼻温（NT）、pH值及血氧饱和度（SPO2）等指标，同时记录麻醉诱导时间，恢复自主呼吸的时间，术中追加麻药例数，术后不良反应例数。结果三组实验猪实验前身长、体重、血红蛋白量及放血量等一般情况比较差异无显著性（P〉0．05）；A组诱导期长，HR和NT升高明显，术中需多次给药并有躁动现象，术后有呕吐等不良反应；B组麻醉比较平稳，但在术中仍有躁动现象且需补加麻药；C组麻醉效果最佳，诱导期短，术中安全，恢复自主呼吸的时间短，术后无不良反应。结论静吸复合麻醉，诱导时间短，麻醉效果好，术中平稳安全，术后苏醒快，适宜巴马小型猪手术麻醉。

Comparative of Three Anesthetic Methods in hemorrhagic shock Experiments of Bama Minipigs

Objective To Comparative study of three anesthetic methods in hemorrhagic shock experiments of Bama Minipigs. Methods Bama Minipigs 24, the average into three groups are Intramuscular ketamine group (A group), intravenous propofol group (B group), propofol intravenous anesthesia with sevoflurane group (C group). Respectively, before anesthesia (T0), after induction (T1), after catheter (T2), HS instantly (T3), HS after 30min (T4), recovery (T5), resuscitation after 30min (T6) and pull the end of the experiment tube after 10 min (T7), pigs in each group were observed and recorded heart rate (HR), mean arterial pressure (MPAP), nasal temperature (NT), pH value and oxygen saturation (SPO2) and other indicators, while recording the induction of anesthesia time, restoration of spontaneous breathing time, intraoperative anesthetic additional number of cases, number of cases of postoperative adverse reactions. Results Three groups of Bama pig experiments predecessor length, weight, volume and put the blood hemoglobin general condition showed no significant difference (P> 0.05); A group of anesthesia to be ineffective, surgery and have to be repeated dosing restless phenomenon surgery after vomiting and other adverse reactions; B group anesthesia is relatively stable, but still restless phenomenon during surgery and need additional anesthetic; C group anesthesia best short induction period, intraoperative safety, restoration of spontaneous breathing short time, intraoperative no adverse effects. Conclusion Propofol intravenous anesthesia combined with sevoflurane anesthesia induction time is short, the anesthetic effect is good, smooth and safe surgery, postoperative recovery fast, suitable for large animal anesthesia.