Relationship between Vitamin D Metabolites and Bone Mineral Density in Young Males: A Cross-Sectional and Longitudinal Study |
| |
Authors: | M Högström A Nordström P Nordström |
| |
Institution: | 1. Sports Medicine, Department of Surgical and Perioperative Science, Ume? University, S-901 85, Ume?, Sweden 2. Department of Community Medicine and Rehabilitation Medicine, Ume? University, S-901 85, Ume?, Sweden 3. Department of Public Health and Clinical Medicine, Ume? University, S-901 85, Ume?, Sweden
|
| |
Abstract: | The purpose of this study was to investigate the association between vitamin D analogs and peak bone mineral density (BMD,
g/cm2) in young men. The cohort consisted of 78 healthy young males with a mean age of 22.6 years at baseline. BMD of the total
body, hip, and spine and lean body mass were measured at baseline and at follow-up 2 years later. Blood samples were assayed
for 25−hydroxyvitamin D2 (25OHD2), 25-hydroxyvitamin D3 (25OHD3), and 25-hydroxyvitamin D (25OHD) at baseline using high-performance liquid chromatography. Levels of 25OHD3 significantly correlated to BMD at all sites and to lean body mass (r = 0.23–0.35, P < 0.05). In contrast, levels of 25OHD2 significantly negatively correlated with BMD of the total body (r = −0.28, P = 0.01) and spine (r = −0.27, P = 0.02). BMD was then adjusted for the influence of age, body weight, body height, and physical activity (hours/week). Level
of 25OHD3 was then found to be an independent predictor of BMD of the total body (beta = 0.24, P = 0.03) and spine (beta = 0.25, P = 0.03), while level of 25OHD2 was an independent negative predictor at the same sites (beta = −0.23 for both, P = 0.03). There was a negative association between levels of 25OHD3 and 25OHD2 (r = −0.31, P = 0.006). In summary, our novel results suggest an inverse relationship between 25OHD3 and 25OHD2 and an opposite relationship of these vitamin D analogs to BMD in young men. |
| |
Keywords: | Bone density Males 25-Hydroxyvitamin D3 25-Hydroxyvitamin D2 |
本文献已被 PubMed SpringerLink 等数据库收录! |
|