微机辅助CT脑灌注成像以及定量测量

目的：报告微机辅助CT脑灌注成像以及定量测量方法。方法：以PentiumⅡ300MHz微处理器，128MB内存，16MB显存，6G硬盘PC机和Windows98第2版为平台，用VissualC 为开发语言，根据中心容积定理，利用动态CT图像分析并计算脑血流动力学的有关参数，包括脑血流量（cerebral blood flow,CBF)，脑血容量（cerebral blood volume,CBV),平均通过时间（mean transit time,MTT)和峰值时间（time to peak,TTP)等。最后，将脑血流动力学数据根据色阶分别处理成脑血流量图（mapping of CBF)，脑血容量图（mapping of CBV)，平均通过时间图（mapping of MTT)和峰值时间图（mapping of TTP)。结果：动态增强CT图像经软件处理后可以在微机上显示脑组织的CBF，CBV，TTP和MTT灌注原始图像以及分割颅骨，皮下组织和脑室后的图像。急性脑缺血患者在MR T1加权像，T2加权像，平扫CT以及增强CT未显示的责任病灶，脑CT灌注图像可以清楚显示脑血流动力学的异常。结论：微机辅助CT脑灌注成像简单铁行，可显示常规CT和MR无法发现的早期脑缺血区的血流异常。与MR灌注成像相比更适用于急诊检查。

Personal computer aided mapping and measurement of cerebral perfusion with dynamic CT

Objective To intruduce a method of making cerebral perfusion mapping and measurement using dynamic CT with a personal computer. Methods We generated the cerebral perfusion mapping and measurement from a series dynamic CT images with a personal computer. The theoretic basis of our technique is central volume principle. The application software was made using visual C++ language with Windows 98 platform. Results This method was applied to a case of transient ischemic attack (TIA). The cerebral perfusion mapping contributed to display the abnormal area of ischemia, which showed as normal imaging appearances in routine CT and MR images. Conclusion Personal computer aided mapping and measurement of cerebral perfusion with dynamic CT is a simple and accessible technique for delineating the hemodynamic response, including abnormal regional cerebral blood flow, blood volume, mean transit time, and time to peak in cases of hyperacute ischemic stroke which was viewed as normal imaging findings in routine CT and MR examination. This method is more suitable to examine emergency cases than MR perfusion imaging and may be used in any facility where CT scanner and personal computer are available.