The effect of each of three physicochemical variables on solute uptake by polyvinylchloride infusion bags

The effect of each of three physicochemical variables, solute concentration, electrolyte concentration and temperature on the uptake of six model solutes by Polyvinylchloride (PVC) infusion containers has been investigated. It has been shown that the solute uptake is independent of the initial concentration of the solute and that both temperature and electrolyte concentration have significant effects on the extent of solute loss. The Arrhenius equation has been used to described the temperature effect on solute uptake into PVC bags. The extent of solute uptake from solution in the presence of electrolytes without large ions is a function of increasing ionic strength. It is suggested that the sorption number which can be used to predict solute uptake needs to be adjusted by the use of correction factors for temperature and for vehicle ionic strength, as appropriate.