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Effect of an inhibitor of aromatization, 1,4,6 androstatriene-3,17-dione (ATD) on LH release and steroid binding in hypothalamus of adult female rats |
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| Authors: | A. Slama F. Gogan A. Sarrieau M. Vial W. Rostene C. Kordon |
| Affiliation: | 1. INSERM Unité 156, Place de Verdun, F-59045, Lille Cédex, France 2. INRA - Physiologie de la Reproduction, F-37380, Monnaie, France 3. INSERM Unité 55, H?pital Saint-Antoine, F-75571, Paris Cédex 12, France 4. INSERM Unité 159, 2ter Rue d'Alésia, F-75014, Paris, France |
| Abstract: | Summary Prevention of testosterone aromatization in the female rat pups by perinatal treatment with 1,4,6 androstatriene-3,17-dione (ATD) induces an important defeminization as shown by a reduction of fluctuations of LH release after castration and estradiol implantation. The fact that, under our in vitro experimental conditions, ATD is able to displace testosterone binding in the hypothalamus whereas estradiol does not, confirms the hypothesis that ATD acts on aromatase. The most attractive explanation for the defeminization effect of ATD is then an estrogen-like action of ATD. |
| Keywords: | ATD Steroid binding sites LH release Hypothalamus Brain sections |
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