| Institution: | 1.Program for Early and Recurrent Pregnancy Loss (PEARL), Department of Obstetrics and Gynecology,Albert Einstein College of Medicine, Montefiore Medical Center,Bronx,USA;2.Department of Obstetrics and Gynecology,Brooklyn Hospital Center,Brooklyn,USA;3.Department of Pathology, Department of Obstetrics & Gynecology,Albert Einstein College of Medicine, Montefiore Medical Center,Bronx,USA;4.Department of Pharmaceutical Sciences,College of Pharmacy and Health Sciences, St. John’s University,Queens,USA |
| Abstract: | Purpose of ReviewChronic endometritis is generally an asymptomatic condition typically diagnosed by the histopathological presence of plasma cell infiltration in the endometrial stromal compartment. Emerging data suggests that chronic endometritis may be a cause of recurrent pregnancy loss (RPL).Recent FindingsChronic endometritis is prevalent in cases of otherwise unexplained recurrent pregnancy loss. Treatment appears to lead to improved pregnancy outcomes in subsequent pregnancies. The use of CD138 immunohistochemistry as a supplement to traditional hematoxylin and eosin staining of plasma cells increases the detection rate of chronic endometritis.SummaryChronic endometritis is emerging as a treatable cause of RPL. |
