The role of complement,immunoglobulin and bacterial antigen in coagulase-negative staphylococcal shunt nephritis |
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Authors: | R.S. Dobrin N.K. Day P.G. Quie H.L. Moore R.L. Vernier A.F. Michael A.J. Fish |
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Affiliation: | Minneapolis, Minnesota, USA |
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Abstract: | We describe three patients with arrested hydrocephalus in whom glomerulonephritis developed secondary to Staphylococcus epidermidis bacteremia from an infected ventriculoatrial shunt. Investigation of the immune-mediated renal disease associated with this chronic infection showed that (1) complement depletion during the acute phase of bacteremia and nephritis was predominantly via the classic pathway; (2) rheumatoid factor was associated with bacteremia, fever, proteinuria and low complement levels; (3) early complement components (C1q, C4, C3), immunoglobulin (predominantly immunoglobulin M [IgM]), Staph. epidermidis antigen(s) and electron dense subendothelial deposits were localized within the renal glomerulus; (4) C1q and IgM derived from patient serums, were the most prominent in vitro immunoreactants to Staph. epidermidis cell walls; and (5) the causative organisms, Staph. epidermidis, shared common antigens with Staph. aureus, and antibody from patient serums cross reacted with extracts from both of these organisms. |
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Keywords: | Requests for reprints should be addressed to Dr. A. J. Fish Department of Pediatrics University of Minnesota Minneapolis Minnesota 55455. |
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