福辛普利和氯沙坦治疗心力衰竭疗效的比较

目的 :比较福辛普利和氯沙坦治疗心力衰竭的疗效及对肾素血管紧张肽系统的影响。方法 :71例心力衰竭病人分为 2组 ,其中 36例病人应用福辛普利 10mg ,qd× 4wk ,35例病人应用氯沙坦50mg ,qd× 4wk。结果 :福辛普利组临床总有效率为 61% ,氯沙坦组为 63% (P >0 .0 5)。 2组治疗前后心率、血压的差值分别为 ( 12± 12 )次·min- 1和 ( 7± 10 )次·min- 1,( 2 .9± 2 .2 ) / ( 4± 3)kPa和 ( 2 .6±0 .9) / ( 3.6± 2 .0 )kPa(均P <0 .0 1)。同时 2组均有减少心肌氧耗、改善心肌缺血范围和程度、改善左室收缩舒张功能等作用。结论 :尽管 2药对肾素血管紧张肽系统作用不同 ,但均对治疗心力衰竭有效

Comparison of fosinopril and losartan for heart failure

AIM: To compare the clinical efficacy of fosinopril and losartan in the treatment of heart failure and its influence to the renin angiotensin system. METHODS: Seventy one patients with heart failure were divided into two groups: fosinopril group 36 patients (M20,F16;age 72 a± s 10 a) received fosinopril 10 mg, qd, for 4 wk; losartan groupt 35 patients (M20, F15; age 69 a±10 a) received losartn 50 mg, qd for 4 wk. RESULTS: The total clinical effective rates of fosinopril group and losartan group were 61% and 63% ( P >0.05). Both groups had the function of reducing heart rate, decreasing blood pressure, improving scope and severity of cardiac ischemia and improving left ventricular systolic and diastolic function. CONCLUSION: Two drugs are effective in the treatment of heart failure though there are different mechanism to renin angiotensin system.