Association between serial dynamic contrast-enhanced MRI and dynamic 18F-FDG PET measures in patients undergoing neoadjuvant chemotherapy for locally advanced breast cancer

Purpose:

To investigate the contrast of three‐dimensional balanced steady state free precession (3D bSSFP) in the two component T2 model and to apply the results to optimize 3D bSSFP for prostate imaging at 1.5 Tesla.

Materials and Methods:

In each of seven healthy volunteers, six 3D bSSFP acquisitions were performed with flip angles (α) equally spaced between 10° and 110°. Predictions of signal and contrast were obtained from synthetic bSSFP images calculated from relaxation parameters obtained from a multi‐spin‐echo acquisition. One biexponential and two monoexponential models were applied. Measured and predicted signals were compared by simple linear regression.

Results:

The measured contrast to signal ratio increased continuously with α. Mean R² for the biexponential model was almost constant for α in the range 50–110°. The biexponential model was a better predictor of the measured signal than the monoexponential model. A monoexponential model restricted to the echoes TE = 50–125 ms performed similar to the biexponential model. The predicted contrast peaked at α between 50° and 90°.

Conclusion:

Prostate imaging with bSSFP benefited from high flip angles. The biexponential model provided good signal prediction while predictions from the monoexponential models are dependent on the range of TE used for T2 determination. J. Magn. Reson. Imaging 2010;31:1124–1131. © 2010 Wiley‐Liss, Inc.