Physiological effects of extracellular nucleotides in the inner ear |
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Authors: | Housley G D |
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Affiliation: | Department of Physiology, University of Auckland, New Zealand. g.housley@auckland.ac.nz |
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Abstract: | 1. Electrochemical homeostasis, sound transduction and auditory neurotransmission in the cochlea are influenced by extracellular purines and pyrimidines. 2. Evidence that ATP and related nucleotides influence inner ear function arises from a considerable number of cellular, molecular and physiological studies in vitro and in vivo. 3. With a full understanding of these processes, which include ionotropic (P2X receptor) and metabotropic (P2Y receptor) signal transduction pathways, signal termination involving ecto-nucleotidases and recycling via nucleoside transporters, exciting possibilities emerge for treating hearing disorders, such as Meniere's disease, tinnitus and sensorineural deafness. |
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Keywords: | ATP auditory neurotransmission cochlea hearing purines P2X receptors P2Y receptors sound transduction |
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