| LGT蛋白质组在创伤性颅脑损伤患者血清中的表达及对病情评估的意义 |
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| 引用本文： | 张刚利,任晋瑞,吉宏明,张汉伟.LGT蛋白质组在创伤性颅脑损伤患者血清中的表达及对病情评估的意义[J].中国药物与临床,2011,11(2):125-127. |
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| 作者姓名： | 张刚利 任晋瑞 吉宏明 张汉伟 |
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| 作者单位： | 山西省人民医院神经外科,太原,030012 |
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| 基金项目： | 国家高技术研究发展计划(863计划)(2006AA02090406A) |
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| 摘 要： | 目的探讨LGT蛋白质组在创伤性颅脑损伤(TBI)患者血清中的表达,初步分析其对病情判断的临床意义,并分析多种临床因素对LGT蛋白质组表达的影响。方法采用表面加强激光解析电离飞行时间质谱(SELDI)技术检测105例TBI患者和20名健康对照者血清LGT蛋白质组的表达,比较LGT蛋白质组在不同程度颅脑损伤组和对照组之间的表达差异,并分析手术、濒死等因素对LGT蛋白质组表达的影响。结果在TBI患者血清中存在LGT蛋白质组的表达。在不同损伤程度患者中,重型TBI组和轻中度TBI组LGT蛋白质组丰度明显高于健康对照组(P<0.01);重型TBI组LGT蛋白质组丰度明显高于轻中度TBI组(P<0.01),重型TBI组LGT蛋白质组阳性率明显高于轻中度TBI组(χ2=9.825,P=0.002)。手术后LGT蛋白质组丰度较术前降低,差异有统计学意义(P<0.05)。濒死患者血清蛋白指纹谱明显低平,波峰减少显著,无LGT蛋白质组的表达。结论 TBI患者血清中存在LGT蛋白质组表达谱。LGT蛋白质组丰度的变化反映了颅脑损伤的严重程度,LGT蛋白质组的表达和手术、濒死等因素密切相关,对患者病情判断有重要意义。
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| 关 键 词： | 颅脑损伤 蛋白质组 生物学标记 |
The expression and prognostic significance of serum LGT proteome in patients with traumatic brain injury |
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| ZHANG Gang-li,REN Jin-rui,JI Hong-ming,ZHANG Han-wei.The expression and prognostic significance of serum LGT proteome in patients with traumatic brain injury[J].Chinese Remedies & Clinics,2011,11(2):125-127. |
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| Authors: | ZHANG Gang-li REN Jin-rui JI Hong-ming ZHANG Han-wei |
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| Institution: | ZHANG Gang-li,REN Jin-rui,JI Hong-ming,ZHANG Han-wei.Department of Neurosurgery,Shanxi Provincial Hospital,Taiyuan 030012,China |
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| Abstract: | Objective To determine the expression of serum lost goodwill target(LGT) proteome as related to prognosis in patients with traumatic brain injury(TBI),and analyze the effects of a variety of clinical factors on the expression of LGT proteome.Methods The LGT proteome in serum samples from 105 TBI patients and 20 healthy volunteers were detected by SELDI to compare the difference in LGT expression between brain injury group and the control group,and to examine a variety of factors,such as surgery and agonal s... |
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| Keywords: | Craniocerebral trauwa Proteme Biological markers |
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