| 气相色谱法同时测定盐酸伊立替康中8种残留溶剂 |
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| 引用本文： | 徐燕,朱圣亮,孙宝祥. 气相色谱法同时测定盐酸伊立替康中8种残留溶剂[J]. 亚太传统医药, 2011, 7(1): 23-25 |
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| 作者姓名： | 徐燕 朱圣亮 孙宝祥 |
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| 作者单位： | 江苏恒瑞医药股份有限公司,江苏,连云港,222002 |
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| 摘 要： | 目的:建立盐酸伊立替康中8种有机溶剂残留量的分离测定方法。方法:采用气相色谱法,色谱柱为SE-54(50m×0.53mm×1.0μm),氢火焰离子化检测器(FID),氮气为载气,程序升温,N,N-二甲基甲酰胺为溶解介质,二氯乙烷为内标物。结果:8种有机溶剂完全分离,线性关系与精密度良好。结论:本方法可用于盐酸伊立替康中有机溶剂残留量的检测。
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| 关 键 词： | 盐酸伊立替康 残留溶剂 气相色谱法 |
Simultaneous Determination of Eight Residual Solvents in Irinotecan Hydrochloride by Gas Chromatography |
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| Xu Yan,Zhu Shengliang,Sun Baoxiang. Simultaneous Determination of Eight Residual Solvents in Irinotecan Hydrochloride by Gas Chromatography[J]. Asia-Pacific Traditional Medicine, 2011, 7(1): 23-25 |
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| Authors: | Xu Yan Zhu Shengliang Sun Baoxiang |
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| Affiliation: | Xu Yan,Zhu Shengliang,Sun Baoxiang(Jiangsu Hengrui Medicine Co.Ltd,Lianyungang 222002,China) |
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| Abstract: | Objective： To develop a method for determination of eight residual solvents in irinotecan hydrochloride. Methods： The residual solvents were determined by GC on SE--54 column（50m×0.53mm×1.0μm）with FID detector, nitrogen as the carrier, N, N-dimethylformamide（DMF） as solvent media, 1,2-diehloroethane as internal standard, the column temperature rose by program. Results：The eight residual solvents in irinotecan hydrochloride can be completely separated, and the calibration curves of each solvent were linear, precision was good too. Conclusion：The method is accurate and reliable. It is suitable for detection of residual sol- vents in irinotecan hydrochloride. |
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| Keywords: | Irinotecan Hydrochloride Residual Solvents GC |
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