Synthesis and <Emphasis Type="Italic">In Vitro</Emphasis> antiproliferative activity of 2-methyl-3-(2-piperazin-1-yl-ethyl)-pyrido[1,2-a]pyrimidin-4-one derivatives against human cancer cell lines |
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Authors: | Lingappa Mallesha Kikkeri N Mohana Bantal Veeresh Ravi Alvala Alvala Mallika |
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Institution: | Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570 006, India. mallesha83@gmail.com |
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Abstract: | A series of new 2-methyl-3-(2-piperazin-1-yl-ethyl)-pyrido1,2-a]pyrimidin-4-one derivatives 6a-j were synthesized by a nucleophilic substitution reaction of 2-methyl-3-(2-piperazin-1-ylethyl)-pyrido1,2-a]pyrimidin-4-one
with various sulfonyl chlorides. The compounds were characterized by different spectral studies. All the compounds were evaluated
for their antiproliferative effect using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay method
against four human cancer cell lines (K562, Colo-205, MDA-MB 231, IMR-32) for the time period of 24 h. Among the series, compounds
6d, 6e and 6i showed good activity on all cell lines except K562, whereas the other compounds in the series exhibited moderate activity.
Compound 6d could be a potential anticancer agent and therefore deserves further research. |
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