Testosterone therapy increased muscle mass and lipid oxidation in aging men |
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Authors: | Louise Frederiksen Kurt H?jlund David M Hougaard Kim Brixen Marianne Andersen |
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Institution: | (1) Department of Endocrinology, Odense University Hospital, Sdr. Boulevard 29, 5000 Odense, Denmark;(2) Institute of Clinical Research, University of Southern Denmark, Odense, Denmark;(3) Department of Clinical Biochemistry and Immunology, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen, Denmark |
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Abstract: | The indication for testosterone therapy in aging hypogonadal men without hypothalamic, pituitary, or testicular disease remains
to be elucidated. The aim of this study was to investigate the effect of testosterone therapy on insulin sensitivity, substrate
metabolism, body composition, and lipids in aging men with low normal bioavailable testosterone levels using a predefined
cutoff level for bioavailable testosterone. A randomized, double-blinded, placebo-controlled study of testosterone treatment
(gel) was done on 38 men, aged 60–78 years, with bioavailable testosterone <7.3 nmol/l and a waist circumference >94 cm. Insulin-stimulated
glucose disposal (Rd) and substrate oxidation were assessed by euglycemic hyperinsulinemic clamps combined with indirect calorimetry.
Lean body mass (LBM) and total fat mass (TFM) were measured by dual x-ray absorptiometry, and serum total testosterone was
measured by tandem mass spectrometry. Bioavailable testosterone was calculated. Coefficients (b) represent the placebo-controlled mean effect of intervention. LBM (b = 1.9 kg, p = 0.003) increased while HDL–cholesterol (b = −0.12 mmol/l, p = 0.043) and TFM decreased (b = −1.2 kg, p = 0.038) in the testosterone group compared to placebo. Basal lipid oxidation (b = 5.65 mg/min/m2, p = 0.045) increased and basal glucose oxidation (b = −9.71 mg/min/m2, p = 0.046) decreased in response to testosterone therapy even when corrected for changes in LBM. No significant changes in
insulin-stimulated Rd was observed (b = −0.01mg/min/m2, p = 0.92). Testosterone therapy increased muscle mass and lipid oxidation in aging men with low normal bioavailable testosterone
levels; however, our data did not support an effect of testosterone on whole-body insulin sensitivity using the euglycemic
hyperinsulinemic clamp technique. |
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Keywords: | Testosterone therapy Insulin sensitivity Substrate oxidation Aging men |
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