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Comparative Investigations on In Vitro Serum Stability of Polymeric Micelle Formulations

Authors:	Tobias Miller Reinhard Rachel Ahmed Besheer Senta Uezguen Markus Weigandt Achim Goepferich

Institution:	(1) Exploratory Pharmaceutical Development, Merck KGaA, Frankfurter Stra?e 250, 64293 Darmstadt, Germany;(2) Center for Electron Microscopy at the Institute for Anatomy, University of Regensburg, Universit?tsstrasse 31, 93040 Regensburg, Germany;(3) Department of Pharmaceutical Technology, University of Regensburg, Universit?tsstrasse 31, 93040 Regensburg, Germany;(4) Dept. of Pharmacy, Pharmaceutical Technology & Biopharmaceutics, Ludwig Maximilians University, 81377 Munich, Germany;

Abstract:	Purpose Stability of polymeric micelles upon injection is essential for a drug delivery system but is not fully understood. We optimized an analytical test allowing quantification of micellar stability in biofluids and applied it to a variety of block copolymer micelles with different hydrophobic block architechtures.

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