High-dose clevudine impairs mitochondrial function and glucose-stimulated insulin secretion in INS-1E cells |
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| Authors: | Yoon-Ok Jang Xianglan Quan Ranjan Das Shanhua Xu Choon-Hee Chung Chan Mug Ahn Soon-Koo Baik In Deok Kong Kyu-Sang Park Moon Young Kim |
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| Affiliation: | (1) Department of Internal Medicine, Yonsei University, Wonju College of Medicine, Wonju, 220-701, Korea;(2) Department of Physiology, Yonsei University, Wonju College of Medicine, Wonju, 220-701, Korea;(3) Department of Basic Science, Yonsei University, Wonju College of Medicine, Wonju, 220-701, Korea;(4) Institute of Lifestyle Medicine, Yonsei University, Wonju College of Medicine, Wonju, 220-701, Korea |
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| Abstract: | Background Clevudine is a nucleoside analog reverse transcriptase inhibitor that exhibits potent antiviral activity against hepatitis B virus (HBV) without serious side effects. However, mitochondrial myopathy has been observed in patients with chronic HBV infection taking clevudine. Moreover, the development of diabetes was recently reported in patients receiving long-term treatment with clevudine. In this study, we investigated the effects of clevudine on mitochondrial function and insulin release in a rat clonal β-cell line, INS-1E. |
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