乳腺浸润性导管癌VEGF、COX-2和ER、PR的表达及意义

目的:探讨血管内皮生长因子(VEGF)、环氧化酶-2(COX-2)和雌、孕激素受体(ER、PR)在乳腺浸润性导管癌中的表达及临床意义。方法:检测100例乳腺浸润性导管癌和40例良性乳腺肿瘤组织中COX-2、VEGF、ER、PR的表达情况,并分析它们与生物学行为的关系。结果:乳腺癌组COX-2阳性率达54%与对照组比较差异有统计学意义;VEGF阳性率为66%,与对照组比较差异有显著性。在ER、PR阴性组中,VEGF、COX-2阳性表达率较高。结论:COX-2、VEGF在乳腺浸润性导管癌组织中的高表达,与乳腺癌的生长、转移有密切关系,可以作为反映乳腺癌生物学行为和判断预后的有效指标。

The Expression of COX-2 ,VEGF,ER,and PR in Breast Cancer and their Significance

Objective: To investigate the expression of vascular endothelial growth factor (VEGF) , cyclooxygenase-2(COX-2) and estrogen receptor(ER) and progesterone receptor(PR) in invasive ductal carcinoma(IDC) of breast and significant. Methods: The method of SP immuneohischemical technique was used to test the expression of COX-2 , VEGF, ER, PR in 100 breast cancer and 40 benign breast lesions.Results: The ratio of positive expression of COX-2 is 54%, having significantly higher than that of the control group. The ratio of positive expression of VEGF is 66%, showing significant difference with that of the control group. The expression of COX-2 , and VEGF has negative correlation compared with that of ER and PR. Conclusion: There was intimate relation between over-expression of VEGF and COX-2 in IDC of breast and metastasis, and they could act as the quota in deciding breast cancer prognosis and curative rate.