合并乙肝病毒感染的结核病患者发生药物性肝炎的临床分析

目的分析合并乙肝病毒感染的结核病患者发生药物性肝炎的临床情况。方法对182例合并乙肝的结核病患者抗结核治疗中的肝功能情况进行回顾性分析。结果两重感染的患者中抗结核药物诱导肝损害的发生率为27.5%。34例（68%）发生在前3个月内。8例患者出现相关肝炎症状,其中纳差、恶心、呕吐症状最常见。16例（32%）需要停药或修改方案,34例（68%）患者经过积极治疗肝功能正常或好转。结论合并乙肝的结核病患者更易发生药物性肝炎。

Clinical Analysis of the TB Patients with Hepatitis B Virus Infection Induced Drug Hepatitis

Objective To analyze the TB patients with hepatitis B virus infection induced drug hepatitis.Methods Retrospective analysis was conducted to investigate the prevalence of the drug induced liver injury among 182 TB patients with hepatitis B virus infection treated during the period from January 1st2008 to January 1st 2012. Results There were 50（27.5%） cases who were anti-tuberculosis drug-induced liver damage among double-infected patients. 34 patients occurred within the first 3 months, accounting for 68.0%. 8 cases occurred related hepatitis symptoms. Anorexia,nausea and vomiting were the most frequent manifestations. 16 cases（32.0%） needed alternate or discontinue the regimens. 34（68.0%） experienced normalization or markedly improved the liver function. Conclusion Liver injury will be more likely to emerge in TB patients with hepatitis B virus infection.