阿托伐他丁对2型糖尿病颈内动脉内-中膜增厚的干预研究

目的观察阿托伐他丁对2型糖尿病颈内动脉内-中膜增厚的影响,探讨阿托伐他丁在2型糖尿病治疗中的作用。方法从收治的2型糖尿病患者中选取颈动脉轻中度增厚的120例,随机分为阿托伐他汀治疗组和对照组,每组60例。对照组在控制饮食、健康锻炼的基础上予以降血糖治疗,治疗组在对照组的基础上给予口服阿托伐他汀治疗。结果经过严格治疗6个月后,治疗组患者颈内-中膜的厚度较治疗前显著降低,差异有统计学意义（P〈0.05）。对照组患者颈内-中膜的厚度较治疗前无明显变化,差异无统计学意义（P〉0.05）。结论阿托伐他丁对2型糖尿病颈内动脉内-中膜增厚的干预效果明显,能降低颈内动脉内-中膜厚度,稳定并逆转粥样斑块,具有良好的临床价值。

Intervention Study of Atorvastatin for Carotid Artery Intima-media Thickness of Type 2 Diabetes

Objective To evaluate the influence the effect of atorvastatin for carotid artery intima-media thickness of type 2 diabetes. Methods 120 patients from march 2011 to November 2012 who were diagnosed with type 2 diabetes as well as carotid artery intima-media thickness were selected,and randomly divided into atorvastatin treatment group（60 patients） and control group（60 patients）. All the patients were on diet and took exercise as hypoglycemic therapy. The patients in atorvastatin treatment group use atorvastatin. Results Compared with before treatment, intima-media thickness in atorvastatin treatment group was improved significantly（P0.05）, the difference was statistically significant. While intima-media thickness in control group was similar（P0.05） with before treatment, the difference was not statistically significant.Conclusion The efficacy of atorvastatin on carotid intima-media thickness in patients with type 2 diabetes is significantly, it is much more valuable for patients with type 2 diabetes.