过敏性紫癜发病机制研究进展

过敏性紫癜(HSP)是小儿最常见的毛细血管变态反应性疾病之一,其发病机制目前尚未完全阐明.研究显示,体液免疫异常是HSP发病的主要机制,尤其是IgA的作用;T细胞功能改变、细胞因子和炎症介质的参与、易感基因等因素在其发病中也起着重要作用.HSP的发病与多种因素相关,因此从免疫学、遗传学等多方面分析有助于深化对HSP发病机制的认识.

Progress in the pathogenesis of Henoch-Schonlein purpura

Henoch-Schonlein purpura(HSP) is one of the most common blood capillary allergic disorder in children, and its pathogenesis has not been well explained. The studies show that the main mechanism of HSP is the abnormality of humoral immunity, and the role of IgA is emphaszed. Meanwhile, many agents such as changes in T cell function,participation of cytokine and mediators of intlammation, suscepti-bility gene and other factors also play an important role in the incidence of HSP. The pathogenesis of HSP can be better understood through extensive analysis of the immunology factors,genetic factors,and so on.