| 耐碳青霉烯类抗生素鲍曼不动杆菌医院获得性肺炎病例分析 |
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| 引用本文： | 陈海红,李华茵,何礼贤,胡必杰,陈雪华,周春妹,高晓东. 耐碳青霉烯类抗生素鲍曼不动杆菌医院获得性肺炎病例分析[J]. 中国感染与化疗杂志, 2010, 10(2): 94-99 |
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| 作者姓名： | 陈海红 李华茵 何礼贤 胡必杰 陈雪华 周春妹 高晓东 |
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| 作者单位： | 复旦大学附属中山医院呼吸科; |
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| 基金项目： | 上海市重点学科建设项目资助编号:B115 |
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| 摘 要： | 目的了解我院重症监护室(ICU)临床分离的碳青霉烯类抗生素耐药鲍曼不动杆菌(CRAb)医院获得性肺炎(HAP)的流行病学及耐药情况,并探讨ICU中CRAb医院获得性肺炎的危险因素。方法采用纸片扩散法测定鲍曼不动杆菌(Ab)对常用抗菌药物的敏感性,对碳青霉烯类抗生素耐药和敏感(CRAb和CSAb)的HAP患者进行1∶1回顾性病例对照研究。结果①CRAb对大部分抗菌药物的耐药率大于45%,仅对氨苄西林-舒巴坦及头孢哌酮-舒巴坦有较高敏感性(耐药率<20%);与CSAb组相比,CRAb组仅对氨曲南的耐药率进一步上升(P<0.05)。②ICU中CRAb的HAP的独立危险因素是分离出病原菌前14d内接受亚胺培南或美罗培南治疗(OR=6.229)、抗生素使用时间过长(OR=1.067)、APACHEⅡ评分≥20(OR=4.572)以及机械通气时间过长(OR=1.170)。CRAb组及CSAb组的抗生素使用时间分别为(21.87±21.19)d和(8.50±6.00)d(P=0.001),机械通气时间分别为(12.53±11.38)d和(5.67±3.72)d(P=0.013)。结论①2006年7月—2008年6月我院IC...
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| 关 键 词： | 鲍曼不动杆菌 碳青霉烯类耐药 医院获得性肺炎 危险因素 |
Analysis of hospital-acquired pneumonia caused by carbapenem-resistant Acinetobacter baumannii |
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| CHEN Haihong,LI Huayin,HE Lixian,HU Bijie,CHEN Xuehua,ZHOU Chunmei,GAO Xiaodong.. Analysis of hospital-acquired pneumonia caused by carbapenem-resistant Acinetobacter baumannii[J]. Chinese Journal of Infection and Chemotherapy, 2010, 10(2): 94-99 |
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| Authors: | CHEN Haihong LI Huayin HE Lixian HU Bijie CHEN Xuehua ZHOU Chunmei GAO Xiaodong. |
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| Affiliation: | Department of Respiratory Medicine/a>;Zhongshan Hospital of Fudan university/a>;Shanghai 200032/a>;China |
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| Abstract: | Objective To study the bacteriological and epidemiological characteristics of nosocomial A.baumannii infections and identify the risk factors associated with acquisition of hospital-acquired pneumonia caused by carbapenem-resistant A.baumannii(CRAb)in intensive care unit(ICU).Methods A retrospective case control study was conducted in patients who had nosocomial pneumonia caused by A.baumannii in ICU between July 1,2006 and June 30,2008.Antibiotic susceptibilities of bacterial isolates were determined by st... |
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| Keywords: | Acinetobacter baumannii carbapenem-resistant hospital-acquired pneumonia risk factor |
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