| Is KPNB3 Locus Associated With Schizophrenia？ |
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| 作者姓名： | Liu LB Hu Y Ju GZ Zhang X Xie L Liu SZ Shi JP Yu YQ Xu Q Fan Y Shen Y Wei J |
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| 作者单位： | [1]Research Center for Genomic Medicine, School of Public Health, Jilin University, Changchun 130021, Jilin, China [2]School of Stomatology, Capital Medical University, Beijing 100050, China [3]The National Center for Genome Research （Beijing）, Beijing 100176, China [4]Ness Foundation, UHI Millennium Institute, Inverness IV3 8GY, U. K. |
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| 基金项目： | This work was supported by the National 863 Program (No. 2001AA221072 and 2004AA221070),the National Key Technology Research and Development Program of China (No. 2002BA711A07),the National Natural Science Foundation of China (No. 39970165 and 30400263),the Beijing Natural Science Foundation (No. 5052021). |
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| 摘 要： | Objective To reconfirm the association of KPNB3 with schizophrenia in Chinese population. Methods Two single nucleotide polymorphisms (SNPs), rs2588014 and rs626716 at the KPNB3 locus, were genotyped in 304 Chinese Han family trios consisting of fathers, mothers, and affected offsprings with schizophrenia. These 2 SNPs were detected by PCR-based restriction fragment length polymorphism (RFLP) analysis. The Hardy-Weinberg equilibrium for genotypic distributions was estimated by the goodness-of-fit test. The UNPHASED program was used to perform transmission disequilibrium test (TDT), haplotype analysis, and pair-wise measure of linkage disequilibrium (LD) between these 2 SNPs. Results The genotypic distributions of both rs2588014 and rs626716 were in the Hardy-Weinberg equilibrium (P>0.05). The TDT revealed allelic association with rs626716 (χ2 =9.31, P=0.0023) but not with rs2588014 (χ2 =3.44, P=0.064). The global P-value was 0.0099 for 100 permutations. The haplotype analysis also showed a disease association (χ2 =25.97, df=3, P=0.0000097). Conclusion The present study provides further evidence in support of the KPNB3 association with schizophrenia in Chinese population.
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| 关 键 词： | 精神分裂症 KPNB3位点 相关性 遗传因素 染色体13 |
| 收稿时间： | 2006-02-05 |
| 修稿时间： | 2006-12-12 |
Is KPNB3 Locus Associated With Schizophrenia |
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| Liu LB,Hu Y,Ju GZ,Zhang X,Xie L,Liu SZ,Shi JP,Yu YQ,Xu Q,Fan Y,Shen Y,Wei J.Is KPNB3 Locus Associated With Schizophrenia[J].Biomedical and Environmental Sciences,2007,20(1):52-55. |
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| Authors: | Liu Li-Bo Hu Ying Ju Gui-Zhi Zhang Xuan Xie Lin Liu Shu-Zheng Shi Jie-Ping Yu Ya-Qin Xu Qi Fan Yu Shen Yan Wei Jun |
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| Abstract: | OBJECTIVE: To reconfirm the association of KPNB3 with schizophrenia in Chinese population. METHODS: Two single nucleotide polymorphisms (SNPs), rs2588014 and rs626716 at the KPNB3 locus, were genotyped in 304 Chinese Han family trios consisting of fathers, mothers, and affected offsprings with schizophrenia. These 2 SNPs were detected by PCR-based restriction fragment length polymorphism (RFLP) analysis. The Hardy-Weinberg equilibrium for genotypic distributions was estimated by the goodness-of-fit test. The UNPHASED program was used to perform transmission disequilibrium test (TDT), haplotype analysis, and pair-wise measure of linkage disequilibrium (LD) between these 2 SNPs. RESULTS: The genotypic distributions of both rs2588014 and rs626716 were in the Hardy-Weinberg equilibrium (P > 0.05). The TDT revealed allelic association with rs626716 (chi2 = 9.31, P = 0.0023) but not with rs2588014 (chi2 = 3.44, P = 0.064). The global P-value was 0.0099 for 100 permutations. The haplotype analysis also showed a disease association (chi2 = 25.97, df = 3, P = 0.0000097). CONCLUSION: The present study provides further evidence in support of the KPNB3 association with schizophrenia in Chinese population. |
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| Keywords: | Chromosome 13 KPNB3 Single nucleotide polymorphisms (SNPs) Schizophrenia |
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