霉酚酸酯治疗慢性原发性肾小球肾炎27例疗效观察

目的研究霉酚酸酯(MMF)治疗慢性原发性肾小球肾炎的临床疗效.方法选择27例慢性原发性肾小球肾炎患者,其中12例经肾活检确诊,予MMF治疗,初始剂量为1.00 g/d,3个月后减量至0.50～0.75g/d,6个月后减到0.25～0.50g/d,疗程至少6个月以上.分治疗前、6个月2个时间点进行自我对照分析.主要观测指标包括内生肌酐清除率、血肌酐、尿蛋白定量、血清白蛋白.结果经MMF治疗,主要表现为尿蛋白定量及血肌酐下降(P＜0.05)、肌酐清除率上升(P＜0.05).副作用包括2例消化道症状、1例带状疱疹,均不需停止用药.结论MMF治疗慢性原发性肾小球肾炎有效,副作用轻微,耐受性好.

Mycophenolate mofetil in treatment of chronic and primary glomerulonephritis

Objective: To investigate the efficacy of mycophenolate mofetil(MMF) on treating chronic and primary glomerulonephritis. Methods: 27 patients with chronic and primary glomerulonephritis were treated by MMF. 12 out of them were confirmed by renal biopsy. The initial dosage of MMF was 1.0 g/d. The dosage was reduced to 0.5~0.75 g/d after three-month treatment. The maintaining dosage was 0.25~0.5 g/d after six months. The duration of MMF treatment was at least six months. Creatinine clearance, serum creatinine, 24 h protein excretion and serum albumin were performed before and six months after MMF treatments. Results: The treatment of MMF increased the creatinine clearance (P<0.05) and decreased the urine protein and serum creatinine (P<0.05). One patient was infected by herpes virus and two patients developed slight diarrhea, others had no side effects. Conclusions: MMF is effective in the treatment of chronic and primary glomerulonephritis. Treatment with MMF associates with less side effect and good tolerance.