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| 福尔肝6号对肝星状细胞增殖的影响 | |
| 引用本文： | 陈文慧,王海南,刘成海,陆青,邓欣,林青,刘平,苏涟.福尔肝6号对肝星状细胞增殖的影响[J].云南中医学院学报,2001,24(4):11-12,15. |
| 作者姓名： | 陈文慧 王海南 刘成海 陆青 邓欣 林青 刘平 苏涟 |
| 作者单位： | 1. 云南中医学院, 2. 上海中医药大学肝病研究所, 3. 上海华山医院, 4. 湖北中医学院, |
| 摘 要： | 目的：探讨福尔肝6号对肝星状细胞增殖影响的抗肝纤维化作用机理。方法：采用血清药理学实验方法作用于活化的大鼠肝星状细胞（HSC），以^3H-TdR掺入法观察肝星状细胞增殖。结果：福尔肝6号和秋水仙碱药物血清能抑制肝星状细胞增殖，福尔肝6号药物血清组优于秋水仙碱药物血清组。结论：福尔肝6号药物血清能抑制HSC的增殖，从而减少胶原等ECM合成。 |
| 关 键 词： | 肝纤维化 福尔肝6号 肝星状细胞 细胞增殖 中医药治疗 大鼠 |
| 文章编号： | 1000-2723(2001)04-0011-02 |
Effects of FUGAN VI on Proliferation of Hepatic stellate cell |
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| CHEN Wen-hui ,WANG Hai-nan ,LIU Cheng-hai ,LU Qing ,DENG Xin ,LIN Qing.Effects of FUGAN VI on Proliferation of Hepatic stellate cell[J].Journal of Yunnan College of Traditional Chinese Medicine,2001,24(4):11-12,15. | |
| Authors: | CHEN Wen-hui WANG Hai-nan LIU Cheng-hai LU Qing DENG Xin LIN Qing |
| Institution: | CHEN Wen-hui 1,WANG Hai-nan 2,LIU Cheng-hai 2,LU Qing 4,DENG Xin 3,LIN Qing 1 |
| Abstract: | Objective:To explore the machanisms of the recipe action against fibrosis and the effects of FUGAN VI on hepatic stellate cell (HSC). Methods:Drug sera was directly added into rat's activated hepatic stellate cells culture medium,and then the proliferation of hepatic stellate cells were assayed by incorporation of 3H-TdR. Results:Drug sera of FUGAN VI and drug sera of colchicine can both inhibit the proliferation of hepatic stellate cells, and the group of FUGAN VI was better than the group of colchicine. Conclusions:Drug sera of FUGAN VI can inhibit proliferation of HSC,thus reducing the synthesis of extracellular stroma such as the collagen and so on. |
| Keywords: | Liver Disease Liver Fibrosis FUGAN VI Hepatic Stellate Cell Extracellular Stroma |
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