| 慢性应激对大鼠学习记忆功能和海马神经细胞粘附分子表达的影响 |
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| 引用本文： | 蔡亦蕴,张伟国,施慎逊.慢性应激对大鼠学习记忆功能和海马神经细胞粘附分子表达的影响[J].上海精神医学,2008,20(5):285-287. |
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| 作者姓名： | 蔡亦蕴 张伟国 施慎逊 |
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| 作者单位： | 复旦大学附属华山院精神科,200040 |
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| 摘 要： | 目的观察慢性应激对大鼠学习记忆功能和海马神经细胞粘附分子（NCAM）表达的影响，探讨海马NCAM表达在慢性应激影响学习记忆机制的作用。方法20只SD大鼠随机被分为对照组（10只）和慢性应激组（10只），后者以束缚浸水应激方式连续应激21天，三周后行水迷宫实验，并用免疫组化法测定大鼠的脑海马区NCAM的表达。结果应激组在水迷宫测试中寻找水中隐藏平台的潜伏期为（7．1±8．9）秒，对照组为（12．3±4．2）秒，差异有统计学意义；穿越平台次数：应激组为（8．4±1．1）次，对照组为（12．5±1．9）次，差异有统计学意义。应激组海马CA3区NCAM的表达：25．2％±3．6％，对照组为37．9％±5．1％，差异有统计学意义。结论慢性应激对大鼠的学习记忆功能有抑制作用。其机制可能与应激抑制海马CA3区NCAM表达有关。
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| 关 键 词： | 慢性应激 认知 神经细胞粘附分子 海马 |
Effects of chronic stress on learning ability and expression of neuronal cell adhesion molecule in hippocampus in rats |
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| Cai Yiyun,Zhang Weiguo,Shi Shenxun.Effects of chronic stress on learning ability and expression of neuronal cell adhesion molecule in hippocampus in rats[J].Shanghai Archives of Psychiatry,2008,20(5):285-287. |
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| Authors: | Cai Yiyun Zhang Weiguo Shi Shenxun |
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| Institution: | Cai Yiyun,Zhang Weiguo,Shi Shenxun. Huashan hospital,Fudan University,Shanghai 200040 |
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| Abstract: | Objective: To investigate the effects of chronic stress on learning ability and the expression of neuronal cell adhesion molecules(NCAM)in hippocampus in rats.Methods: Twenty SD male rats were randomly divided into stress group(n=10)and control group(n=10).Three weeks later, Morris water maze test was performed to assess the spatial learning ability.The brains were immediately removed for determination of NCAM expression in CA3 of hippocampus using immuno-histochemical staining technique. Results:The latent... |
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| Keywords: | Chronic stress Learning ability Neural cell adhesion molecules(NCAM) Hippocampus |
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