| ERCC-1和RRM-1在非小细胞肺癌组织中的表达及病理的临床分析 |
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| 引用本文： | 陈伟文,王志刚,沈冰寒,郭伟峰,叶晓艺,郑锦阳.ERCC-1和RRM-1在非小细胞肺癌组织中的表达及病理的临床分析[J].临床肺科杂志,2013,18(2):215-216. |
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| 作者姓名： | 陈伟文 王志刚 沈冰寒 郭伟峰 叶晓艺 郑锦阳 |
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| 作者单位： | 福建医科大学附属泉州市第一医院呼吸内科;福建医科大学附属泉州市第一医院病理科 |
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| 摘 要： | 目的研究切除修复交叉互补基因ERCC1、核苷酸还原酶调节因子RRM1在非小细胞肺癌中的表达及其临床价值。方法选择非小细胞肺癌患者作为观察组,肺部良性病变患者作为良性对照组、体检者作为健康对照组,采用SurPlexTM液相芯片技术检测肺癌组织中ERCC1、RRM1的mRNA相对含量。结果观察组患者肺癌组织中ERCC1、RRM1的mRNA含量明显高于良性病变对照组和健康对照组,且呈现出TNMⅠ
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| 关 键 词： | 非小细胞肺癌 DNA修复 切除修复交叉互补基因1 核苷酸还原酶调节因子 |
Expression of ERCC-1 and RRM-1 in non-small cell lung cancer tissues and the clinical analysis |
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| CHEN Wei-wen,WANG Zhi-gang,SHEN Bing-han,GUO Wei-feng,YE Xiao-yi,ZHENG Jin-yang.Expression of ERCC-1 and RRM-1 in non-small cell lung cancer tissues and the clinical analysis[J].Journal of Clinical Pulmonary Medicine,2013,18(2):215-216. |
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| Authors: | CHEN Wei-wen WANG Zhi-gang SHEN Bing-han GUO Wei-feng YE Xiao-yi ZHENG Jin-yang |
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| Institution: | 1.Respiratory Medicine,Fujian Medical University Affiliated Quanzhou First Hospital,Fujian 362000;2.Pathology Medicine,Fujian Medical University Affiliated Quanzhou First Hospital,Fujian 362000 |
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| Abstract: | Objective To study the expression of ERCC-1 and RRM-1 in non-small cell lung cancer tissues and its clinical value. Methods non-small cell lung cancer patients as the observation group, benign lung lesions patients as benign control group, physical examination subjects as healthy control group, using SurPlexTM liquid chip technology to detect ERCC1 and RRM1 mRNA content in lung tissue. Results ERCC1, RRM1 mRNA content of observation group were significantly higher than benign and healthy control group, showing TNM I 〈 TNM Ⅱ 〈 TNMm 〈 TNMIV. Conclusion ERCC1 and RRM1 mRNA content in lung cancer was higher than benign lesions and healthy tissue and has a certain significance in the diagnosis. |
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| Keywords: | non-small cell lung cancer DNA repair ERCC-1 RRM-1 |
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