谷胱甘肽硫转移酶基因多态性与疾病关系的研究进展

谷胱甘肽硫转移酶(GSTs)由谷胱甘肽与亲电子物组成,大多数可与蛋白质或DNA发生反应。某些情况下(如在卤化物溶剂中),谷胱甘肽的结合物可以导致毒性及突变物增加。GSTs属于Ⅱ相抗氧化酶家族,是一种具有细胞解毒作用的蛋白质。目前大多采用的分类方法主要是根据GSTs亚基N末端氨基酸序列的同源性,考虑到各种GSTs的底物特异性、免疫反应性和对不同抑制剂的敏感性,将哺乳动物的GSTs分为GSTM1、GSTM3、GSTP1和GSTT1。现就GSTs基因多态性与其涉及的疾病予以概述。

Research Progress of Correlation between Diseases and Glutathione S-transferases Gene Polymorphism

Glutathione S-transferases(GSTs)is consisted of glutathione and electrophilic substance,most of which can act with protein and DNA.In some cases(such as halogenated solvent),glutathione conjugation may cause toxicity and increased mutation.GSTs belong to Phase II antioxidant enzyme family,and has antidotal function.At present,most classification methods are based on the homology of GSTs subunit N terminal amino acid sequence,zymolyte specificity,immune response and sensitivity to different inhibitors of GSTs.Mammalian GSTs are classified as GSTM1,GSTM3,GSTP1and GSTT1.Here is to make a review on GSTs gene polymorphism and the related diseases.