Propafenone-Induced Torsade de Pointes: Cross-Reactivity with Quinidine |
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Authors: | JOHN TY HII D GEORGE WYSE ANNE M GILLIS JAMES M COHEN L BRENT MITCHELL |
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Institution: | Department of Medicine and the Department of Pharmacology and Therapeutics, Foothills General Hospital and University of Calgary, Calgary, Alberta, Canada |
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Abstract: | A 77-year-oid/emale with new onset atrial fibrillation occurring in the absence of structural heart disease developed torsade de pointes during therapy with quinidine bisulfate 500 mg orally every 8 hours. Ten days after quinidine therapy had been discontinued she developed torsade de pointes while receiving propafenone 300 mg orally every 8 hours. This case demonstrates that propafenone may be associated with torsade de pointes and suggests a cross-reactivity between this effect and prior occurrence of torsade de pointes on Class IA antiarrhythmic drug therapy. |
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Keywords: | propafenone quinidine torsade de pointes ventricular tachycardia proarrhythmia |
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