| 缺氧缺血性脑病患儿NO、NOS水平与脂质过氧化关系的研究 |
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| 引用本文： | 陈传兵,张玉红,周秀娟,尹洪霞,王娜,李华.缺氧缺血性脑病患儿NO、NOS水平与脂质过氧化关系的研究[J].放射免疫学杂志,2008,21(6). |
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| 作者姓名： | 陈传兵 张玉红 周秀娟 尹洪霞 王娜 李华 |
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| 作者单位： | 1. 江苏省东海县人民医院新生儿科,222300
2. 江苏省东海县人民医院检验科,222300 |
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| 基金项目： | 江苏省连云港市卫生局科研项目
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| 摘 要： | 目的:探讨了缺氧缺血性脑病患儿血清NO、NOS水平与脂质过氧化的关系.方法:应用生化法对30例缺氧缺血性脑病患儿进行了血清NO、NOS测定和化学比色法测定血清丙二醛(MDA)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-PX)含量,并以35名正常健康人作比较.结果:缺氧缺血性脑病患儿血清NO、SOD、GSH-PX水平显著低于正常人组(P＜0.01),而NOS、MDA水平则显著高于正常人组(P＜0.01),相关分析显示:血清NO、SOD、GSH-PX水平与MDA水平呈明显负相关(r=-0.4286、-0.4125、-0.4108,P＜0.05).结论:缺氧缺血性脑病患儿血清NO、SOD、GSH-PX水平的降低与活性代谢紊乱密切相关.
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| 关 键 词： | 缺氧缺血性脑病患儿 一氧化氮 一氧化氮合成酶 丙二醛 超氧化物歧化酶 谷胱甘肽过氧化物酶 |
Study on the Relationship Between the Serum NO,NOS Levels and Lipid Peroxidation in Neonates with Hypoxic-Ischemic Encephalopathy |
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| Chen Chuanbing,Zhang Yuhong,Zhou Xiujuan,et al..Study on the Relationship Between the Serum NO,NOS Levels and Lipid Peroxidation in Neonates with Hypoxic-Ischemic Encephalopathy[J].Journal of Radioimmanology,2008,21(6). |
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| Authors: | Chen Chuanbing Zhang Yuhong Zhou Xiujuan |
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| Institution: | Chen Chuanbing,Zhang Yuhong,Zhou Xiujuan,et al.Jiangsu Donghai County People\'s Hospital(222300) |
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| Abstract: | Objective To assess the relationship between the serum NO,NOS levels and lipid peroxidiation in neonates with hypoxic-ischemic encephalopathy.Methods Serum NO,NOS levels(with biochemistry),MDA,SOD and GSH-PX levels(with colorimetry) were measured in 30 neonates with hypoxid-ischemic encephalopathy and 35 controls.Results Serum NO,SOD and GSH-PX levels were significantly lower in neonate patients with hypoxic-ischemic encephalopathy than those in controls(P<0.01) while the serum NOS,MDA levels were significa... |
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| Keywords: | hypoxic-ischemic encephalopathy nitric oxide(NO) nitric oxide synthase(NOS) malondialdohyde(MDA) superoxide dismutase(SOD) glutathione peroxidase(GSH-PX) |
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