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CNS-active substances: synthesis of epoxybenzoxocines |
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| Authors: | B Wünsch |
| Affiliation: | Institut für Pharmazie und Lebensmittelchemie, Universit?t München. |
| Abstract: | The 2-(2-Bromophenyl)-acetaldehyde acetals 8 are treated with n-BuLi and the aldehydes 7 and 11 to form the hydroxyacetales 9 and 12, respectively. 9 is cyclized under acidic conditions to the epoxybenzoxocine 2; analogously 12 yields the epoxydibenzoxocine 14. |
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